In a News and Views commentary entitled "To BE or not to BE, that is the question", Dr. Jia Chen at School of Life Science and Technology (SLST) of ShanghaiTech University, together with Dr. Bei Yang at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University and Dr. Li Yang at CAS-MPG Partner Institute for Computational Biology (PICB) of Chines...

A team of scientists led by SLST Professor Dr. Hu Ji has discovered a new mechanism of stress coping and published their research, titled "Reward Inhibits Paraventricular CRH Neurons to Relieve Stress" in Current Biology. People encounter stressful stimuli every day.  Chronic, long-term stress can lead to various pathologies, including cardiovascular disease, inflammation, meta...

School of Life Science and Technology Associate Professor Tiffany Horng published a review article entitled "Metabolism as a guiding force for immunity" in Nature Cell Biology in January 2019, in collaboration with Mayo Clinic Assistant Professor Hu Zeng to publish a review article. This article reviews recent studies that have elucidated how the metabolism of immune cells plays an ...

A team of scientists led by Dr. Guan Ji-Song at the School of Life Science and Technology at ShanghaiTech has decoded the role of retrosplenial cortex in contextual fear conditioning, retrieval and extinction with in vivo two-photon imaging and TRAP. They discovered the extinction memory engrams in retrosplenial cortex and artificially controlled the level of fear by manipulating different memory ...

In a new paper published in Developmental Cell, a team of researchers from ShanghaiTech University, Shenzhen Institutes of Advanced Technology, Tsinghua University, Johns Hopkins University and National Institute of Biological Sciences developed a powerful strategy and valuable reagents to systematically probe histone functions in Drosophila melanogaster.Associate Professor Gao Guanjun from the Sc...

A team of scientists led by Dr. Zhou Tao from ShanghaiTech’s School of Life Science and Technology, Dr. He Chuan from University of Chicago and Dr. Song Hongjun from University of Pennsylvania, have made a breakthrough in the field of RNA methylation (m6a) in regulating brain functions. Their work, entitled “m6A Facilitates Hippocampus-Dependent Learning and Memory through YTHDF1” was published...

On October 19th to 20th, SLST held its sixth annual Frontier of Genome Engineering (FoGE2018). Vice President and Provost Yin Jie delivered opening remarks, highlighting the remarkable progress that ShanghaiTech University has achieved. The conference was officially opened by SLST Vice Dean Professor Liu Jilong, who focused on the SLST’s achievements in the last few years. Nearly 400 researchers ...

CRISPR-Sirius, a sensitive and bright imaging system, has been developed by research groups led by Dr. Ma Hanhui at ShanghaiTech University and Dr. Thoru Pederson at the University of Massachusetts Medical School. Their study was recently published in Nature Methods, a prestigious scientific journal.CRISPR-Sirius makes it possible to detect low-copy repeats distributed in the intergenic and genic ...

A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang from ShanghaiTech’s School of Life Science and Technology and Dr. Li Yang from the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel base editors (BEs) using a spectrum of cytidine deaminases from different species, including human APOBEC3A (hA3A). Their work, ...

Cell and cellular organelles communication are often controlled by the membrane protein interaction. Despite the many existing methods to detect protein-protein interactions (PPIs), there are still challenges in detecting membrane PPIs. Transient and weak PPIs are mostly associated with membrane receptor-mediated signaling pathways. Mass spectrometry-based membrane protein interaction studies have...

A recent international research collaboration has shed new light on DNA replication. The collaboration, led by Professor Bo Sun from the School of Life Science and Technology at ShanghaiTech University and Professor Michelle D. Wang from the Howard Hughes Medical Institute (HHMI) and Cornell University, revealed a new replication recovery pathway. Their paper, “Helicase Promotes Replication Re-in...

The prognosis of late stage cancer patients after traditional cancer treatments such as radiation, surgery and chemotherapy is always poor. Immunotherapy with antibodies targeting immune checkpoints represents a major breakthrough in cancer treatment. Some cases of patients previously consideredincurable are now able to be cured through immunotherapy. However, only a fraction of patients show...

Lin Haifan, Founding Dean of School of Life Science and Technology (SLST) of ShanghaiTech, Yale University Professor of Cell Biology and Reproductive Sciences and Director of the Yale Stem Cell Center, was among 213 academics newly elected as members of the American Academy of Arts and Sciences (AAAS), which celebrates excellence in a wide range of disciplines.Professor Lin’s work focuses on the ...

An international effort within the immunology research community resulted in the first genome-wide CRISPR screen focused on the molecular mechanism of T cell function regulation. A group of scientists led by Dr. Haopeng Wang of ShanghaiTech’s School of Life Science and Technology, along with Dr. Arthur Weiss at UCSF and Dr. Lai Wei of the Zhongshan Ophthalmic Center at Sun Yat-sen University...