On November 10-14th, the 2019 ShanghaiTech BioForum was successfully held at ShanghaiTech University. For the first time, the BioForum was jointly organized by the three life science institutions of ShanghaiTech University - School of Life Science and Technology (SLST), Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and iHuman Institute (iHuman), which compose the “ShanghaiTech Li...

A tumor immunogenicity score (TIGS), a novel cancer immunotherapy biomarker, was proposed by a research team from the School of Life Science and Technology (SLST) led by Assistant Professor Liu Xuesong. The study describing TIGS was published online in the journal eLife on November 26th. This tumor immunogenicity-based biomarker could guide the treatment to transform some immunotherapy n...

A study published in Genome Biology systematically compares a panel of BEs for the first time and BEable-GPS is the first database to profile the accessibility of BEs to target pathogenic SNVs. BEable-GPS and its embedded toolsets will provide researchers a great resource for their experimental designs to model or correct disease-related mutations.This study results from a collaboration betwe...

Research teams led by Professor Sun Bo from SLST and Professor Shen Bin from Nanjing Medical University have completed a high-resolution quantitative map of Cas9/sgRNA/DNA interactions (Figure 1). On November 13, 2019, their study was published as a research article entitled, “The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation," in the journal...

On August 29th, 2019, a study led by a collaboration between ShanghaiTech Adjunct Professor Rao Zihe and SLST Adjunct Professor and CAS Institute of Biophysics Hu Junjie’s group was published online in Nature Communications. In the research article, “Mycobacterial dynamin-like protein IniA mediates membrane fission,” they reported the crystal structure of IniA, an isoniazid inducible protein, w...

When the undergraduate Class of 2019 crosses the stage to receive their diplomas this month, they represent the best ShanghaiTech has to offer. The paths they took converged for four years on campus together, and now they prepare to head off in different directions. School of Life Science and Technology graduating senior Zhang Yuxi’s college experience didn’t start out so well. She felt dis...

SLST Professor Shen Wei’s lab, in collaboration with Huazhong University of Science & Technology Professor Li Haohong’s Lab, have discovered a novel mechanism of predatory hunting and reward feeding. Their research, published on May 23rd in an article in Nature Neuroscience entitled “Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to...

A team of scientists led by SLST’s Dr. Zhang Hui and CAS Shanghai Institute of Biochemistry and Cell Biology’s Dr. Zhou Bin, has discovered a new mechanism for neonatal heart regeneration. Their findings suggest that cellular senescence that occurs after heart injury plays an essential role in neonatal heart regeneration. Their work, entitled “CCN1-Induced Cellular Senescence Promotes Heart Reg...

A team of scientists led by SLST’s Dr. Qi Wei from and Dr. Song Baoliang from Wuhan University has identified Gpnmb as a liver-secreted factor promoting lipogenesis in white adipose tissue and aggravating obesity and insulin resistance. Using neutralizing antibody, they also demonstrated that reducing circulating Gpnmb brought therapeutic benefit to obesity and diabetes in animal models. This stu...

Assistant Professor Yuu Kimata at School of Life Science and Technology published a review article titled ‘APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 Phase in Multicellular Systems’ in Trends in Cell Biology in April 2019. The article reviews the recent progress on the molecular function of a protein complex, the Anaphase Promoting Complex/Cyclosome (APC/C), which is...

Recently, a research group led by iHuman Institute and SLST Assistant Professor Zhong Guisheng, working with collaborators SLST Assistant Professor He Shuijin and Southeast University Professor Chai Renjie, used a super-resolution fluorescence microscope to identify novel cytoskeleton ultrastructures in inner ear hair cell. Their two studies, “A cytoskeleton structure revealed by super-resolution...

On April 12, Professor Matthew Freeman FRS, head of the Sir William Dunn School of Pathology at University of Oxford, visited ShanghaiTech.ShanghaiTech President Jiang Mianheng, together with SLST undergraduates, graduate students and postdocs welcomed the professor at a lunchtime gathering where they shared their ideas about potential collaborations. Before lunch, Vice President and Provost Yin J...

A team of scientists led by Dr. Hu Ji from ShanghaiTech’s SLST and Shanghai Jiao Tong University School of Medicine’s Dr. Xu Tian-le has discovered a new mechanism of itch processing.Itching is an interesting experience consisting of two seemingly opposing components: pruritogen-induced aversion and scratching-induced hedonic feelings. In this study, the joint research team reported on the midbr...

In a News and Views commentary entitled "To BE or not to BE, that is the question", Dr. Jia Chen at School of Life Science and Technology (SLST) of ShanghaiTech University, together with Dr. Bei Yang at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University and Dr. Li Yang at CAS-MPG Partner Institute for Computational Biology (PICB) of Chines...