A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang of the School of Life Science and Technology at ShanghaiTech University, along with Dr Li Yang of the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel CRISPR/Cpf1 (Cas12a) bases editors. The paper entitled “Base editing with a Cpf1– cytidine deaminase fusion”...

Nature Neuroscience recently published a study demonstrating that the transcription of multiple genes in the brain can be simultaneously activated using CRISPR–dCas9-activator transgenic mice. This work was performed by researchers in Dr. YANG Hui’s lab at the Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Techn...

A team of scientists led by Dr. Jia Chen in the School of Life Science and Technology at ShanghaiTech University, Dr. Li Yang in the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, and Dr. Bin Shen in the State Key Laboratory of Reproductive Medicine in the Department of Histology and Embryology at Nanjing Medical University has revealed that APOBEC3 induces...

ShanghaiTech’s School of Life Science and Technology (SLST) held the 5th Annual ShanghaiTech BioFrontier Conference -- Frontier of Genetics and Genomics (FoGG2017) on October 20-21st, 2017, in the auditorium of the newly completed L building, the home of SLST.Nearly 300 researchers from leading institutions gathered at the conference to present and discuss cutting-edge progress in a broad sp...

A team led by Assistant Professor Huang Pengyu at ShanghaiTech University’s School of Life Science and Technology, collaborating with Sun Yat-sen Memorial Hospital at Guangzhou, found an important role of IGF-2 in liver regeneration induced by some chronic liver injuries. Their work entitled “Pericentral hepatocytes produce IGF-2 to promote liver regeneration during special injuries” was publis...

Genome editing is a type of genetic engineering, which utilizes programmable nucleases such as the Cas9 nuclease to achieve desired base insertion, deletion or substitutions in the genome of living organisms. Directed by guide RNA (gRNA), Cas9 nuclease can generate DNA double strand breaks (DSBs) at targeted genomic sites. Subsequent resolving of the generated DSB through non-homologous end joinin...

A team of scientists led by Dr. Huang Xingxu at the School of Life Science and Technology at ShanghaiTech and Dr. Liu Jiang at the Beijing Institute of Genomics, Chinese Academy of Sciences, has successfully described the chromatin interaction map of mice with male and female gametes and early embryos at different developmental stages and revealed global chromatin architecture reprogramming during...

ShanghaiTech’s first NanoTemper Forum of Tumor Immunotherapy attracted nearly 200 attendees from academia, clinical practice and industry. The forum was jointly sponsored by the Shanghai Association for Science and Technology, Shanghai Society of Biophysics and ShanghaiTech’s School of Life Science and Technology.An opening ceremony was held on June 27 with a welcome from vice president and prov...

Recently, Dr. Wei L. Shen’s group from ShanghaiTech University has published a research article in Proceedings of the National Academy of Sciences titled with “A hypothalamic circuit that controls body temperature.” They have elucidated a neural mechanism responsible for heat defensive behavior.Thermal homeostasis is essential for survival in mammals. Significant deviation of body temperat...