Cerebral blood flow regulation is vital for brain homeostasis and optimal functionality, impacting neuronal survival and the performance of neural circuits. Altered blood flow has been widely observed in various conditions, including emotional arousal, depression, PTSD, Alzheimer’s disease, and stroke. However, the mechanisms underlying blood flow control remain elusive. In this talk, I will present a novel neurovascular coupling mechanism mediated by synapse-like transmission and explore how Ca2+-driven myogenic spontaneous vasomotion regulates blood flow to safeguard the brain after ischemic stroke.