ShanghaiTech University

Angewandte Chemie

Researchers Unveil New Universal Anticancer Chemical Mechanism

Cancer is one of the biggest killers threatening human life and chemotherapy, which kills cancer cells with molecular drugs that are toxic to cells, is one of the main ways to treat cancer. For metastatic tumors, chemotherapy is the most effective method. However, chemotherapy drugs can also kill a large number of normal cells, causing severe toxic side effects and seriously damaging the physical ...

2019-04-20
IEEE Transactions on Power Electronics

Novel GaN-Based DC/DC Module Proposed

Recently, SIST Assistant Professor Fu Minfan proposed a 300W 110V/24V digital DC/DC module based on gallium nitride (GaN) devices. The proposed module can achieve 95.8% peak efficiency and 195 W/inch3 power density, which are much better than the state of the art (Synqor’s module: 91% peak efficiency and 80 W/inch3 power density). Recently, his work on magnetic design and high-frequency digital c...

2019-02-20
Cell

Cross-Disciplinary Research Published in Same Issue of Cell

On January 25th, iHuman Institute and Shanghai Institute for Advances in Immochemical Science (SIAIS) held a joint press conference to announce the simultaneous publishing of two important research studies in the same issue of the prestigious Cell journal. Having two research studies in the same issue of a journal is rare, said Distinguished Adjunct Professor Rao Zihe, one of the co-corr...

2019-01-25
IEEE Transactions on Power Electronics

Highly Efficient E-Vehicle Advanced Power Electronic Converter Proposed

Recently, School of Information Science and Technology Assistant Professor Wang Haoyu’s research group proposed a highly efficient LLC resonant topology for plug-in electric vehicle charging applications. Their work, “A Five-Switch Bridge Based Reconfigurable LLC Converter for Deeply-Depleted PEV Charging Applications,” was recently published in IEEE Transactions on Power Electronics.This ...

2018-11-14
Nature Methods

CRISPR-Sirius: ShanghaiTech and UMass Scientists Develop a Novel Technique to Image 4D Genome Organization

CRISPR-Sirius, a sensitive and bright imaging system, has been developed by research groups led by Dr. Ma Hanhui at ShanghaiTech University and Dr. Thoru Pederson at the University of Massachusetts Medical School. Their study was recently published in Nature Methods, a prestige scientific journal.CRISPR-Sirius makes it possible to detect low-copy repeats distributed in the intergenic and genic reg...

2018-10-31
Science

New Electron Transfer Mechanism from a Mycobacterial Respiratory Supercomplex Discovered

On October 25th, ShanghaiTech Distinguished Professor-in-Residence Rao Zihe and his team’s research on “An electron transfer path connects subunits of a mycobacterial respiratory supercomplex” was published online in Science journal.On the strength of cryo-electron microscopy (cryo-EM) with high resolution (3.5 Å) structure of mycobacterial respiratory supercomplex, the team revealed a new elec...

2018-10-25
Methods in Molecular Biology

SIAIS ADC Chem Lab Publishes a Volume for Methods in Molecular Biology

Research Associate Professor Liu Jia from SIAIS Professor Jiang Biao’s ADC Chemistry Lab has completed editing the 1867 volume of Methods in Molecular Biology (MiMB) with titled “Zinc Finger Proteins: Methods and Protocols,” now available from Springer, Amazon and other booksellers.The MiMB series, providing methods and protocols in molecular biology, was founded by editor John Walker in 1...

2018-10-19
Joule

2D-Quasi-2D-3D Hierarchy Structure for Tin Perovskite Solar Cells with Enhanced Efficiency and Stability

Recently, School of Physical Science and Technology Professor Ning Zhijun’s research group developed a 2D-quasi-2D-3D hierarchy structural tin perovskite photovoltaic materials. Tin perovskite solar cells (PSCs) based on this structure achieved a power convention efficiency (PCE) of 9.41%, which is the highest steady-state PCE of lead-free PSCs reported up to now. Their work was recently publishe...

2018-10-10
Science Advances

SPST Research Group Teamwork Leads to Discovery of New Semiconductor

Recently, successful teamwork by several SPST research groups (including those of Professors Chen Yulin, Liu Zhongkai, Xue Jiaming and Li Gang) and Peking University Professor Peng Hailin’s group has made remarkable progress in the understanding of the electronic structures of a new layered oxide semiconductor Bi2O2Se. Their work was published in the September issue of Science Advances, wit...

2018-10-08
Angewandte Chemie

SPST Researchers Develop Novel Method for Chiral Indole Derivatives Synthesis Through Chiral Anion Catalysis

School of Physical Science and Technology (SPST) Professor Yang Xiaoyu’s research group has developed a novel method for chiral indole derivatives synthesis through chiral anion catalysis. Their work, 'Regioselective and Enantioselective Synthesis of β-Indolyl Cyclopentenamides by Chiral Anion Catalysis' was recently published in Angewandte Chemie International Edition, a top chemical jo...

2018-10-08
IEEE Comm

Generalized Sparse and Low-Rank Optimization for Ultra-Dense Networks: Models, Algorithms and Theory

Professor Shi YuanMing and his collaborators at HKUST and Tsinghua University have recently developed large-scale sparse and low-rank frameworks for optimizing across the communication, computation and storage resources in ultra-dense networks (UDNs), thereby providing principled ways to design communication-efficient mobile artificial intelligence (AI) systems and intelligent internet-of-things (...

2018-08-31
Nano Letters

Edge State Engineering of Graphene Nanoribbons

Research teams led by Dr. Yu Ping and Dr. Li Gang of the School of Physical Science and Technology have found a new way for engineering the zigzag edge state of Graphene Nanoribbons with atomic precision. Their work, entitled “Edge State Engineering of Graphene Nanoribbons,” was published online in Nano Letters on August 15, 2018.Graphene nanoribbon, a novel one-dimensional graphe...

2018-08-31
Nature

iHuman Team Deciphers First Human Frizzled Receptor Structure

The Xu Laboratory at ShanghaiTech’s iHuman Institute has deciphered the high-resolution crystal structure of the first human Frizzled receptor. As a gatekeeping protein in regulating the fundamental Wnt signaling in embryonic development and tumorigenesis, the Frizzled receptors (FZDs) have been cancer drug targets for decades without success.However, these results, which illustrate the unique ar...

2018-08-23
Nature Biotechnology

Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion

A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang from ShanghaiTech’s School of Life Science and Technology and Dr. Li Yang from the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel base editors (BEs) using a spectrum of cytidine deaminases from different species, including human APOBEC3A (hA3A). Their work, ...

2018-08-20

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