ShanghaiTech University

Science

Candidate Material for Room-Temperature Quantum Spin Hall Effect Discovered

In condensed-matter physics, the states of matter are classified conventionally as metal, insulator, and semiconductor. In the last few years, a new field has emerged which led to the discovery of a new quantum phase of matter – topological insulators (TIs). A topological insulator, like a conventional insulator, has a bulk energy gap separating the highest occupied electronic band from the lowest...

2017-08-09
Cell

3D Structure of Mature Gametes and Reprogramming Dynamics during Mammalian Embryogenesis Revealed

A team of scientists led by Dr. Huang Xingxu at the School of Life Science and Technology at ShanghaiTech and Dr. Liu Jiang at the Beijing Institute of Genomics, Chinese Academy of Sciences, has successfully described the chromatin interaction map of mice with male and female gametes and early embryos at different developmental stages and revealed global chromatin architecture reprogramming during...

2017-07-20
Nature

Agonist-bound Marijuana Receptor CB1 Structure Determined

A team of scientists led by Professor Liu Zhijie at ShanghaiTech’s iHuman Institute has determined the 3-dimensional molecular structure of the agonist-bound human cannabinoid receptor CB1. The work reveals the structural features of agonist-bound CB1 and the activation mechanism of the receptor. The results, described in a paper entitled "Crystal structures of agonist-bound human canna...

2017-07-14
Nature

Multi-domain Structure of Human Smoothened Receptor Deciphered

A team of scientists led by the iHuman Institute of ShanghaiTech University in collaboration with Fudan University has determined the high-resolution crystal structure of the multi-domain human smoothened receptor. The results illustrate the allosteric domain-domain interactions within the receptor, and their role in smoothened activation. These new findings are published on May 17th, 2017 in...

2017-05-18
Nature

Key Diabetes Receptor Structure Determined

An international team led by the iHuman Institute, ShanghaiTech University has determined the 3-dimensional molecular structure of the human glucagon-like peptide-1 receptor (GLP-1R) drug binding domain. The work reveals molecular mechanisms of allosteric regulation in class B G protein-coupled receptors (GPCRs). The results, described in a paper entitled “Human GLP-1 receptor transmemb...

2017-05-18
Advanced Materials

High Efficiency and Low Toxicity Photocatalytic Hydrogen Generation Material Developed

a. Scheme of 0D-2D nanocomposite for hydrogen generation under illumination; b. Hydrogen generation performance of nanocomoposite with QDs before and after ligand exchange; c. Hydrogen generation performance of nanocomposites with different concentration of MoS2.School of Physical Science and Technology Professor Ning Zhijun’s team recently made progress on photocatalytic hydrogen generation. The...

2017-04-21
JACS

New Bacterial Superbug Genome Editing Tool Developed

The Ji Lab at The School of Physical Science and Technology has developed a CRISPR/Cas9-based system (pCasSA) for rapid and efficient genome editing in Staphylococcus aureus, a major human pathogen that causes serious infections with a high mortality rate. Their work was recently published online in the Journal of the American Chemical Society in a paper titled “Rapid and Effi...

2017-02-28
Science

Novel Selective Methionine Bioconjugation Method Developed

Post-translational modification (PTM) plays an important role in regulating the physiological activity of proteins, controlling the enzyme catalytic activity and protein-protein recognition in the biological process. The chemical modification of proteins can study the physiological mechanism of proteins by mimic PTM process, as well as tracking proteins in vitro/vivo and developing therapeuti...

2017-02-17
Science

Novel Selective Methionine Bioconjugation Method Launched

Post-translational modification (PTM) plays an important role inregulating the physiological activity of proteins, controlling the enzymecatalytic activity and protein-protein recognition in the biological process. The chemical modification of proteins can study the physiological mechanism of proteins by mimicking PTM process, as well as tracking proteins invitro/vivoand developing therapeutic pro...

2017-02-17
PNAS

Discovery of Neural Mechanism for Body Temperature Regulation Revealed

Recently, Dr. Wei L. Shen’s group from ShanghaiTech University has published a research article in Proceedings of the National Academy of Sciences titled with “A hypothalamic circuit that controls body temperature.” They have elucidated a neural mechanism responsible for heat defensive behavior.Thermal homeostasis is essential for survival in mammals. Significant deviation of body temperat...

2017-01-05

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