ShanghaiTech University

Journal of Molecular Cell Biology

Groundbreaking Study Offers New Entry Point in Triple Negative Breast Cancer Research

Recently, SIAIS’s Stem Cell Biology Lab has revealed a new mechanism of Wnt/β-catenin signaling pathway activation in triple-negative breast cancer, which was published as a cover story in Journal of Molecular Cell Biology with the title "MiR-221/222 activate the Wnt/beta-catenin signaling to promote triple negative breast cancer."Breast cancer is the most invasive type of cancer ...

2018-08-17
Science

Selective functionalization of methane, ethane, and higher alkanes by cerium photocatalysis

96Normal0falsefalsefalseEN-USZH-CNX-NONEThe Zuo Group at the School of Physical Science and Technology recently developed a photocatalytic methane conversion methodology which can directly transform methane, ethane and other gaseous alkanes into value-added liquid product. This breakthrough in organic chemistry provides a novel, green and mild catalytic platform for natural gas utilization, and co...

2018-07-27
Chemical Science

New Method Uses CNFs to Grow MOFs On Polymeric Surfaces

Normal0falsefalsefalseEN-USZH-CNX-NONEResearch groups led by Professor Tao Li and Chao Zhong from the School of Physical Science and Technology (SPST) at ShanghaiTech University have co-developed a method that can grow metal-organic frameworks (MOFs) on nearly any polymeric surfaces using bacterial adhesive curli nanofibers (CNFs) as a mediator. Their work, “Adhesive Bacterial Amyl...

2018-06-26
Nature Communications

Single-Molecule Technique Reveals New Pathway That Rescues Replication Fork From Barriers

A recent international research collaboration has shed new light on DNA replication. The collaboration, led by Professor Bo Sun from the School of Life Science and Technology at ShanghaiTech University and Professor Michelle D. Wang from the Howard Hughes Medical Institute (HHMI) and Cornell University, revealed a new replication recovery pathway. Their paper, “Helicase Promotes Replication Re-in...

2018-06-15
Advanced Materials

Engineered Bacteria Could Direct Dynamic Assembly of Inorganic Nano-objects with Spatiotemporal Control

Zhong Chao’s Group in the Division of Materials and Physical Biology at ShanghaiTech’s School of Physical Science and Technology (SPST) has recently reported an engineered bacterium, which could sense environmental signals (for example, light or small molecules) to produce biofilms and, and simultaneously direct the assembly of inorganic nano-objects with spatiotemporal control in a dynamic, rec...

2018-05-23
Oncogene

Research Team Finds Immunotherapy Response Predictive Biomarkers

The prognosis of late stage cancer patients after traditional cancer treatments such as radiation, surgery and chemotherapy is always poor. Immunotherapy with antibodies targeting immune checkpoints represents a major breakthrough in cancer treatment. Some cases of patients previously consideredincurable are now able to be cured through immunotherapy. However, only a fraction of patients show...

2018-05-14
Nature Reviews Materials

Nanofibrils in Nature and Materials Engineering Reviewed

Professor Shengjie Ling of School of Physical Science and Technology at ShanghaiTech University, in collaboration with Professor David L. Kaplan of Tufts University and Markus J. Buehler of Massachusetts Institute of Technology published a review article of “Nanofibrils in nature and materials engineering” in Nature Reviews Materials on April 5th.Biopolymer nanofibrils, such as cellulose, c...

2018-04-20
PNAS

Genome-Wide CRISPR Screen Identifies FAM49B as Key Regulator of Actin Dynamics and T Cell Activation

An international effort within the immunology research community resulted in the first genome-wide CRISPR screen focused on the molecular mechanism of T cell function regulation. A group of scientists led by Dr. Haopeng Wang of ShanghaiTech’s School of Life Science and Technology, along with Dr. Arthur Weiss at UCSF and Dr. Lai Wei of the Zhongshan Ophthalmic Center at Sun Yat-sen University...

2018-04-19
Proceedings of the National Academy of Sciences

Mechanistic Insights into Staphylopine-Mediated Metal Acquisition

Recently, Dr. Ji Quangjiang’s group from the School of Physical Science and Technology deciphered the molecular mechanism of how the pathogen Staphylococcus aureus utilizes staphylopine (StP) to recognize and capture metal ions from its surroundings.Their research was published in an article in Proceedings of the National Academy of Sciences titled “Mechanistic insights into staph...

2018-04-17
Nature Communications

Origin of Attractive Forces Between Like-Charged Colloidal Particles Solved

A research team led by Professor Chen Gang of the School of Physical Science and Technology at ShanghaiTech University has solved the long-standing mystery of the origin of the attractive forces between like-charged colloidal particles. Their work was recently published in the prestigious journal Nature Communications.Colloids adsorbed at a fluid interface are ubiquitous in nature and central to a...

2018-04-17
IUCrJ

Three-Dimensional Ultrastructural Imaging Reveals Nanoscale Architecture of Mammalian Cells

A team of scientists led by Professor Huaidong Jiang and Professor Zhi Liu of the School of Physical Science and Technology at ShanghaiTech University, along with Professor Chunying Chen of the National Center for Nanoscience and Technology of China, Professor Renzhong Tai of the Shanghai Institute of Applied Physics have made important progress in the field of bioimaging based on synchrotron radi...

2018-04-09
Frontiers in Psychology

Group Facial Width-to-Height Ratio predicts Intergroup Negotiation Outcomes

In our daily lives, we often have to make quick judgments about strangers based on very little information. The face, as a distinct cue for social communication, is particularly useful for inferring individual characteristics in interpersonal judgment and decision making. The facial width-to-height ratio (FWHR) is one cue that people implicitly use to determine the extent to which men might be tru...

2018-04-04
Nature Biotechnology

Novel CRISPR/Cpf1 (Cas12a) Base Editors Developed

A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang of the School of Life Science and Technology at ShanghaiTech University, along with Dr Li Yang of the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel CRISPR/Cpf1 (Cas12a) base editors. The paper entitled “Base editing with a Cpf1– cytidine deaminase fusion” ...

2018-03-28
Chemical Science

Highly Efficient Base Editing in Staphylococcus Aureus Using an Engineered CRISPR RNA-guided Cytidine Deaminase

Recently, a collaboration between the Ji Lab at the School of Physical Science and Technology, and Beijing Institute of Genomics’s Han Lab developed a single-base editing technique in Staphylococcus aureus and their results were published online in Chemical Science in an article titled, “Highly Efficient Base Editing in Staphylococcus aureus Using an Engineered CRISPR RNA-guided C...

2018-03-15

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