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G protein-coupled receptors (GPCRs) located at the cell surface bind extracellular ligands and convey intracellular signals via activation of heterotrimeric G proteins. Traditionally, G protein signaling was viewed to occur exclusively at this subcellular region followed by rapid desensitization facilitated by β-arrestin-mediated G protein uncoupling and receptor internalization. However, emergin...

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Cryo-EM is a powerful technique that can visualize biomolecules in their near-native state, but suffers from the low contrast of biospecimens and their sensitivity to electron radiation. A phase plate addresses this challenge by shifting the phase of the unscattered beam by exactly 90 degrees relative to the scattered electrons, thereby enhancing image contrast. In this talk I will present the de...

Mitophagy is a selective form of autophagy for clearance of damaged mitochondria via the autophagy-lysosome pathway. Among various mitophagy regulatory mechanisms, PINK1, a protein kinase, and Parkin, an E3 ligase, are two critical players, with important implications in neurodegenerative disorders such as Parkinson's disease (PD). In this presentation, I will cover some of our recent work, includ...

Otolaryngology, commonly known as ENT, offers a unique convergence of sensory physiology, airway biomechanics, and human communication, making it an ideal domain for translational innovation. In this talk, Dr. Yike Li presents a multidisciplinary journey integrating neuroengineering, informatics, and clinical science. The first part introduces advances in neurostimulation for obstructive sleep apn...

Primum Non Nocere, Secundum Simulare: A New Era in Clinical Trials In silico trials (ISTs) and computational medicine are poised to transform medical device development and regulation, embodying the principle of "Do No Harm by Design". This talk explores how ISTs can address the limitations of traditional clinical trials, including high costs, lengthy timelines, and safety concerns. By s...