Targeting different liver cancer hallmarks to boost immunotherapy response
Hepatocellular carcinoma (HCC) is a highly genetically heterogeneous malignancy with variable responses to immunotherapy. To improve therapeutic outcomes, it is essential to understand how different tumor-intrinsic features influence immune responses. In this study, we employ somatic genome-editing mouse models to establish a panel of murine HCC models with diverse genetic backgrounds. These model...
2026-05-17