Cellular homeostasis relies on highly coordinated quality-control systems that monitor protein integrity, organelle function, and genome stability. Among these, ubiquitin-dependent signaling and selective autophagy form an integrated network that safeguards cells against proteotoxic, metabolic, and genotoxic stress. Beyond their classical roles in protein degradation, ubiquitin pathways orchestrat...

Optical imaging is unequivocally a most versatile and widely used visualization modality in the life sciences. Yet it has been significantly limited by photon scattering, which complicates the visualization of tissue beyond a few hundred microns. For the past few years, there has been an emergence of powerful new optoacoustic and fluorescence imaging methods that offer high resolution imaging beyo...