ShanghaiTech University

3D-STED Super-Resolution Microscopy Unravels the Mystery of Astrocytes at the Tripartite Synaptic Function

Professor Katsuhiko Mikoshiba from SIAIS, with the French Professor Valentin Nägerl’s group unraveled the morphological mystery of astrocytes. Misa Arizono, a former PhD student in Mikoshiba’s lab is the first author of this report in Nature Communications 2020.Astrocytes, which are the most numerous...

2020-09-16
Shen Wei’s Lab Clarifies the Mechanism by Which Parabrachial Neurons Types Categorically Encode Thermoregulation Variables During Heat Defense

On September 2nd 2020, Professor Shen Wei from SLST with his collaborators published a research paper entitled “Parabrachial neuron types categorically encode thermoregulation variables during heat defense”, in the international academic journal Science in Advances. This paper defined two key elements of the lateral parabrachial nucleus (LPB)-hypothalamic preoptic area (POA) circu...

2020-09-04
Communication-Efficient Edge AI: Algorithms and Systems

Prof. Shi Yuanming’s research group and collaborators from HKUST and HKPolyU have surveyed the key techniques for improving the communication efficiency of performing artificial intelligence (AI) training and inference tasks at network edges, a.k.a., edge AI. Edge AI is envisioned to promote the paradigm shift of futuristic 6G networks from “connected things” to “connected inte...

2020-09-01
SLST Proposes Novel Necroptosis Regulation Mechanisms

Recently, two groups from the School of Life Science and Technology (SLST) at ShanghaiTech University, led by Prof. Wang Huayi and Prof. Lu Junxia, published a research article entitled “RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif” in Cell Death & Differentiation. Necroptosis is a type of programmed necrosis induced by ...

2020-08-24
SLST Researchers Solve the Controversy over Cellular Sources of Embryonic Vessels

A research team led by Professor Zhang Hui from School of Life Science and Technology (SLST) at ShanghaiTech University has demonstrated that erythro-myeloid progenitors (EMPs) are the origin of resident macrophages in multiple organs, but not the origin of intraembryonic vascular endothelial cells. The team has written an article entitled “No Evidence for Erythro-Myeloid Progenitor-Derived Vascu...

2020-08-24
SLST Researchers Reveal the Dynamics of SaCas9 in DNA Target Association and Dissociation

A research team led by Professor Sun Bo from SLST has systemically investigated the molecular mechanism governing DNA binding, unwinding and cleavage by SaCas9. They provided a detailed dynamic understanding of SaCas9 in DNA target association and dissociation. In addition, two stable interactions between SaCas9 and DNA governing their interplay have been identified. On August 13, this study ...

2020-08-13
SIAIS and University of Queensland Researchers Unveil the Complete Structures of Plant and Fungal Acetohydroxyacid Synthase: The First Enzyme in the Branched-Chain Amino Acid Biosynthesis Pathway

At 11 PM (Beijing Time) on 8th July, a new research finding was reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Professor Luke Guddat (Visiting Professor at SIAIS and Professor at University of Queensland). The related research article entitled “Structures of fungal...

2020-07-09
SLST Researchers Report a Novel Mechanism of Linear Ubiquitination Regulating Autophagy Initiation and Maturation

Recently, a research article entitled “LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13” was published online in Autophagy. This work was done by Professor Liu Yanfen’s group from the School of Life Science and Technology (SLST) at ShanghaiTech University. Autophagy is a self-eating sys...

2020-06-30
Top Diabetes Drug Target Structure Published by International Collaboration Led by iHuman Institute, ShanghaiTech University

Researchers from the iHuman Institute at ShanghaiTech University, Chinese Academy of Sciences (Shanghai Institute of Materia Medica, SIMM), East China Normal University, University of Southern California, and the Danish biopharmaceutical company, Novo Nordisk, have determined the first “peptide-free inactive structure of the full-length human glucagon like peptide-1 receptor (GLP-1R) at atomic re...

2020-03-10
SLST Researchers Report a Novel Unwinding Model of a DNA Repair-Involved Helicase

Recently, different research teams led by Professor Sun Bo from SLST and Professor Xi Xu-Guang from French National Centre for Scientific Research (CNRS) have collaboratively published a research article entitled “Human RPA activates BLM's bidirectional DNA unwinding from a nick” in the journal eLife, revealing a novel unwinding model of a DNA-repair-involv...

2020-03-09
CRUIS Captures RNA-Protein Interaction

Groups of professors Liu Ji-Long，Zhuang Min, and Lu Pengfei from the School of Life Science and Technology (SLST) at ShanghaiTech University have jointly developed a new method CRUIS, or CRISPR-based RNA-United Interacting System, for capturing RNA-protein interactions on specific RNAs. It is a hybrid of two molecular machineries, CRISPR-based RNA-targeting Cas nuclease (dCas13a) and a proximity-...

2020-03-07
Discovery of Novel GPCR Modulators Through Affinity Mass Spectrometry-Based Screening of Herbal Extracts

Recently, Prof. Shui Wenqing’s group from iHuman Institute and SLST has made a breakthrough in bioactive screening from herbal extracts. Based on their previous work in developing the affinity mass spectrometry (MS) technique for ligand screening (Chemical Science 2018, Analytical Chemistry 2019), they combined affinity MS-based screening with compound isolation and ...

2020-03-03
SIST Liu Yu’s Research Group Publishes Two Papers in IEEE Transactions on Power Delivery

Recently, Professor Liu Yu’s group from Center for Intelligent Power and Energy Systems (CiPES) of SIST, proposed two accurate fault location methods on long and complex transmission lines. These two papers were published online in IEEE Transactions on Power Delivery, the best peer-reviewed journal in the field of power system protection, transmission and distribution. High-voltage long...

2020-03-02
3D Protein Structures Help the Orphan Receptor Find Its Way Home: Scientists Uncovered the 3D Structures of an Orphan GPCR and Published Their Results in Nature

Recently, scientists from Xu Fei's lab at iHuman Institute, ShanghaiTech University with their collaborators made a new breakthrough in the field of human cell signaling research. They successfully resolved the 3D protein structures of the first human orphan GPR52 receptor and presented a full structural landscape covering the receptor’s different functional states: ligand-free state, ligand-...

2020-02-20

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