ShanghaiTech University

SLST Proposes Novel Necroptosis Regulation Mechanisms

Recently, two groups from the School of Life Science and Technology (SLST) at ShanghaiTech University, led by Prof. Wang Huayi and Prof. Lu Junxia, published a research article entitled “RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif” in Cell Death & Differentiation. Necroptosis is a type of programmed necrosis induced by ...

2020-08-24
SLST Researchers Solve the Controversy over Cellular Sources of Embryonic Vessels

A research team led by Professor Zhang Hui from School of Life Science and Technology (SLST) at ShanghaiTech University has demonstrated that erythro-myeloid progenitors (EMPs) are the origin of resident macrophages in multiple organs, but not the origin of intraembryonic vascular endothelial cells. The team has written an article entitled “No Evidence for Erythro-Myeloid Progenitor-Derived Vascu...

2020-08-24
SLST Researchers Reveal the Dynamics of SaCas9 in DNA Target Association and Dissociation

A research team led by Professor Sun Bo from SLST has systemically investigated the molecular mechanism governing DNA binding, unwinding and cleavage by SaCas9. They provided a detailed dynamic understanding of SaCas9 in DNA target association and dissociation. In addition, two stable interactions between SaCas9 and DNA governing their interplay have been identified. On August 13, this study ...

2020-08-13
SIAIS and University of Queensland Researchers Unveil the Complete Structures of Plant and Fungal Acetohydroxyacid Synthase: The First Enzyme in the Branched-Chain Amino Acid Biosynthesis Pathway

At 11 PM (Beijing Time) on 8th July, a new research finding was reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Professor Luke Guddat (Visiting Professor at SIAIS and Professor at University of Queensland). The related research article entitled “Structures of fungal...

2020-07-09
SLST Researchers Report a Novel Mechanism of Linear Ubiquitination Regulating Autophagy Initiation and Maturation

Recently, a research article entitled “LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13” was published online in Autophagy. This work was done by Professor Liu Yanfen’s group from the School of Life Science and Technology (SLST) at ShanghaiTech University. Autophagy is a self-eating sys...

2020-06-30
Top Diabetes Drug Target Structure Published by International Collaboration Led by iHuman Institute, ShanghaiTech University

Researchers from the iHuman Institute at ShanghaiTech University, Chinese Academy of Sciences (Shanghai Institute of Materia Medica, SIMM), East China Normal University, University of Southern California, and the Danish biopharmaceutical company, Novo Nordisk, have determined the first “peptide-free inactive structure of the full-length human glucagon like peptide-1 receptor (GLP-1R) at atomic re...

2020-03-10
SLST Researchers Report a Novel Unwinding Model of a DNA Repair-Involved Helicase

Recently, different research teams led by Professor Sun Bo from SLST and Professor Xi Xu-Guang from French National Centre for Scientific Research (CNRS) have collaboratively published a research article entitled “Human RPA activates BLM's bidirectional DNA unwinding from a nick” in the journal eLife, revealing a novel unwinding model of a DNA-repair-involv...

2020-03-09
CRUIS Captures RNA-Protein Interaction

Groups of professors Liu Ji-Long，Zhuang Min, and Lu Pengfei from the School of Life Science and Technology (SLST) at ShanghaiTech University have jointly developed a new method CRUIS, or CRISPR-based RNA-United Interacting System, for capturing RNA-protein interactions on specific RNAs. It is a hybrid of two molecular machineries, CRISPR-based RNA-targeting Cas nuclease (dCas13a) and a proximity-...

2020-03-07
Discovery of Novel GPCR Modulators Through Affinity Mass Spectrometry-Based Screening of Herbal Extracts

Recently, Prof. Shui Wenqing’s group from iHuman Institute and SLST has made a breakthrough in bioactive screening from herbal extracts. Based on their previous work in developing the affinity mass spectrometry (MS) technique for ligand screening (Chemical Science 2018, Analytical Chemistry 2019), they combined affinity MS-based screening with compound isolation and ...

2020-03-03
SIST Liu Yu’s Research Group Publishes Two Papers in IEEE Transactions on Power Delivery

Recently, Professor Liu Yu’s group from Center for Intelligent Power and Energy Systems (CiPES) of SIST, proposed two accurate fault location methods on long and complex transmission lines. These two papers were published online in IEEE Transactions on Power Delivery, the best peer-reviewed journal in the field of power system protection, transmission and distribution. High-voltage long...

2020-03-02
3D Protein Structures Help the Orphan Receptor Find Its Way Home: Scientists Uncovered the 3D Structures of an Orphan GPCR and Published Their Results in Nature

Recently, scientists from Xu Fei's lab at iHuman Institute, ShanghaiTech University with their collaborators made a new breakthrough in the field of human cell signaling research. They successfully resolved the 3D protein structures of the first human orphan GPR52 receptor and presented a full structural landscape covering the receptor’s different functional states: ligand-free state, ligand-...

2020-02-20
The Effective Tailoring of the Spin Texture in Engineered Magnetic Topological Insulator Heterostructures

Magnetic topological insulators (MTIs), which integrate both topology and magnetism within one system, have greatly broadened the research scope of quantum materials and spintronics. In contrast to the traditional magnetic atom doping method, MTI heterostructures, which can be realized by the combination of a topological insulator and a high-temperature magnetic material, have unique advantages. I...

2020-02-16
ShanghaiTech Scientists Decipher the Structures of Signaling Forms of Human “Marijuana Receptors”

A team of scientists led by Professors Liu Zhi-Jie and Hua Tian at the iHuman Institute of ShanghaiTech University has determined and analyzed the high-resolution atomic structures of human cannabinoid receptors, also known as the “marijuana receptors”, 1 and 2 (CB1 and CB2) complexed with their agonists and downstream signaling G proteins. The results, described in a paper entitl...

2020-01-30
PLOS Biology

Uncovering the molecular mechanism of an evolved Cas9 nuclease

Research teams led by SPST Assistant Professor Ji Quanjiang and Fudan University Professor Gan Jianhua recently used structural biology, biochemical, and cell-based genome editing experiments to reveal the mechanisms of the PAM expansion and fidelity enhancement of a new evolved Cas9 nuclease xCas9. Their work, “Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuc...

2020-01-13

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