Dr. Xie’s laboratory uses Drosophila ovarian stem cells as a model system to elucidate niche structures and functions and the mechanisms underlying self-renewal, differentiation, stem cell competition and aging. Additionally, his lab has demonstrated the roles of various signaling pathways (BMP, Hh, Wnt, Notch and cAMP-PKA), cadherin-mediated cell adhesion, epigenetic factors, non-coding RNAs and various protein complexes (COP9, CCR4-NOT and eIF4) in the regulation of self-renewal and differentiation. Recently, his lab has also been using mice to uncover the molecular mechanisms underlying human degenerative eye diseases and further develop stem cell and gene therapies for these diseases, including AMD and glaucoma. Dr. Xie has published over 80 articles in high-profile journals, including Science, Nature and Cell. He received Hudson Award in 2003 and has been serving on the scientific advisory board of The Glaucoma Foundation and the Y-LOT Foundation and on the editorial board of Cell Research, Development and ten other international scientific journals.
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