Fibroblasts and the extracellular matrices they contribute support many different cell and tissue types in the body. They are also indispensable for tissue repair and for the regeneration of organs and limbs. Prof. Rinkevich is making significant contributions to the how fibroblast populations contribute to wound healing, cancerous growth, and tissue development. He is also making ground-breaking contributions in how prefabricated extracellular matrices (ECM) that incorporate fibroblasts, adipose tissues, immune cells, neurovascular tissues and sensor neurons are involved in scaring of internal organs and skin after injury. He observed that specific fibroblasts contribute to scar formation through their adhesion properties and migration (swarming) behaviors, while other fibroblast populations do not. He also discovered that fibroblasts generate scarring by mobilizing prefabricated ECM into the wound surface and that impairing the cell-cell adhesion involved in fibroblast swarming significantly reduces scar formation. Prof. Rinkevich has published these and other important discoveries in Nature (2023, 2019) Nature Communications (2023, 2020), Nature Protocols (2023), Nature Immunology (2022), Nature Cell Biology (2018), Science Translational Medicine (2018) and Science (2015).
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