Integrative Structure Prediction of Biomolecules and Their Complexes
Deep learning has revolutionized protein structure prediction, yet challenges remain in modeling difficult proteins with few homologs and multi-domain complexes. To address this, we developed DeepMSA2, a pipeline that constructs unified multiple sequence alignments through iterative genomic database searches. These MSAs significantly enhance prediction accuracy for both monomers and complexes. Bui...
2025-11-13