Professor Katsuhiko Mikoshiba from SIAIS, with the French Professor Valentin Nägerl’s group unraveled the morphological mystery of astrocytes.  Misa Arizono, a former PhD student in Mikoshiba’s lab is the first author of this report in Nature Communications 2020.Astrocytes, which are the most numerous...

On September 2nd 2020, Professor Shen Wei from SLST with his collaborators published a research paper entitled “Parabrachial neuron types categorically encode thermoregulation variables during heat defense”, in the international academic journal Science in Advances. This paper defined two key elements of the lateral parabrachial nucleus (LPB)-hypothalamic preoptic area (POA) circu...

Prof. Shi Yuanming’s research group and collaborators from HKUST and HKPolyU have surveyed the key techniques for improving the communication efficiency of performing artificial intelligence (AI) training and inference tasks at network edges, a.k.a., edge AI.  Edge AI is envisioned to promote the paradigm shift of futuristic 6G networks from “connected things” to “connected inte...

Recently, two groups from the School of Life Science and Technology (SLST) at ShanghaiTech University, led by Prof. Wang Huayi and Prof. Lu Junxia, published a research article entitled “RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif” in Cell Death & Differentiation.  Necroptosis is a type of programmed necrosis induced by ...

A research team led by Professor Zhang Hui from School of Life Science and Technology (SLST) at ShanghaiTech University has demonstrated that erythro-myeloid progenitors (EMPs) are the origin of resident macrophages in multiple organs, but not the origin of intraembryonic vascular endothelial cells. The team has written an article entitled “No Evidence for Erythro-Myeloid Progenitor-Derived Vascu...

A research team led by Professor Sun Bo from SLST has systemically investigated the molecular mechanism governing DNA binding, unwinding and cleavage by SaCas9. They provided a detailed dynamic understanding of SaCas9 in DNA target association and dissociation. In addition, two stable interactions between SaCas9 and DNA governing their interplay have been identified. On August 13, this study ...

At 11 PM (Beijing Time) on 8th July, a new research finding was reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Professor Luke Guddat (Visiting Professor at SIAIS and Professor at University of Queensland). The related research article entitled “Structures of fungal...

In a review article entitled “A Tale of Two Moieties: Rapidly-evolving CRISPR/Cas-based Genome Editing”, Prof. Chen Jia at School of Life Science and Technology (SLST) of ShanghaiTech University and Prof. Yang Li at CAS-MPG Partner Institute for Computational Biology (PICB) of Chinese Academy of Sciences, summarized recent progress about the development and application of gene editing tools...

A research team from iHuman Institute of ShanghaiTech University has made a new discovery in the field of human chemokine system. This study fills in a critical gap, which is how endogenous chemokines activate endogenous chemokine receptors. The article, entitled Structure basis of CXC chemokine receptor 2 activation and signaling was published in the prestigious journal Nature, available onl...

Recently, a research article entitled “LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13” was published online in Autophagy. This work was  done by Professor Liu Yanfen’s group from the School of Life Science and Technology (SLST) at ShanghaiTech University.  Autophagy is a self-eating sys...

On June 18, a research article entitled “Intellectual disability associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs” was published online in EMBO Reports. This work was done by Liu Ru-Juan’s group in the School of Life Science and Technology (SLST) at ShanghaiTech University and Wang En-Duo’s group from Shanghai Institute of Biochemistry and Cel...

On June 1, 2020, ShanghaiTech University and the Publications Division of the American Chemical Society (ACS) announced their first publishing collaboration to create a new journal for the worldwide research community - Accounts of Materials Research. This important journal launch marks the first global publishing partnership for the two organizations, supporting both their missions and their...

A team led by Professor Chi Tian from School of Life Science and Technology (SLST) at ShanghaiTech University proposed a new therapeutic strategy for IPEX-like disorders in a mouse model. They convert defective regulatory T cells (Treg) into super-activated Tregs (SuperTreg). The paper, entitled In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in...

Since the beginning of 2020, a total of 29 academic papers from the Visual & Data Intelligence Center of SIST have been accepted by top-tier international conferences, covering research hotspots including computer vision, machine learning, natural language processing, computer graphics, and multi-agent systems. Those research outcomes address a variety of real-world problems in digital enterta...