On June 3, 2020, a research article entitled “Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response” was published online in Cell Reports.  This work was done by a team led by Dr. Chen Jia from School of Life Science and Technology (SLST) at ShanghaiTech University, Dr. Yang Li from CAS-MPG Partner Institute for Computational Biology and Dr. L...

Recently, Angewandte Chemie International Edition published a collaborative study led by Professors Richard A. Lerner and Yang Guang from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University, entitled “A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries”. This paper has been highlighted as Very Important Paper (Top 5%...

The 3C protease has long been the focus of enterovirus antiviral development. Nevertheless, although anti-enterovirus drugs have a potentially enormous global market, the nucleophilic active site of 3C has frustrated previous drug discovery efforts. Recently, a team of scientists led by Dr. Yang Bei and Dr. Ian A. Wilson from the Laboratory of Antibody Structure at the Shanghai Institute for ...

Recently, Ning Zhijun's research group from School of Physical Science and Technology has reported a new type of infrared up-conversion photodetector based on colloidal quantum dots (CQDs) with low-cost and high-efficiency (Figure 1). The results was published in Nature Electronics with the title "Solution-processed up-conversion photodetectors based on quantum dots". ...

On May 8, 2020, the Founding Ceremony was held for the Anti-Tuberculosis (TB) Structure Center (A-TB Center) of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University. The ceremony was followed by the First Academic Symposium of the A-TB Center at SIAIS. President Jiang Mianheng and Professor Rao Zihe at SIAIS, Member of the Chinese Academy of Sciences (CAS), joi...

A research group led by Prof. Katsuhiko Mikoshiba from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University proposes a novel and simple method for creating a stable cytoplasmic antibody, termed STAND, which can be correctly folded and stably expressed in the cytoplasm of the cells. Without the need for complicated amino acid substitutions, it successfully conve...

On 29 April 2020, a research work carried out collaboratively by Professors Qi Hai and Zhong Yi from Tsinghua University and Professor Hu Ji from the School of Life Science and Technology (SLST) of ShanghaiTech University was published in Nature entitled “Brain control of humoral immune responses amenable to behavioural modulation”. The researchers identify a specific brain-spleen neur...

Recently, Professor Yu Yi's research group from School of Physical Science and Technology, in collaboration with the research team of Purdue University, have made important progress in the research of novel semiconductor heterostructures. For the first time, two-dimensional halide perovskite lateral epitaxial heterostructures have been successfully synthesized and characterized. On April 29, 2...

Researchers at the iHuman Institute of ShanghaiTech University have made another discovery in the advancement of human health, this time involving an important protein for controlling obesity - the melanocortin-4 receptor. The research is to be published in the prestigious journal Science, available online from April 24, 2020. The Stevens lab which led the work has been intensely focused...

At 2:00 AM (Beijing Time) on 24th April, a research article titled “Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol” as reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), was published via First Release in Science. This work, for...

Recently, Research Associate Professors Liu Jia, from Lab of Macromolecular Drug Delivery and Ma Peixiang,from Lab of Phenotypic Screening at SIAIS, ShanghaiTech University, reported the first anti-CRISPR peptides. These peptides are derived from the periplasmic domain of the major coat protein G8P (G8PPD) of inoviridae bacteriophages and can allosterically inactivate...

On April 10, 2020, a joint research team led by Rao Zihe, Distinguished Adjunct Professor at SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, Wang Quan, Assistant Professor at School of Life Science and Technology (SLST) and SIAIS, ShanghaiTech University and Lou Zhiyong, Research Professor at Tsinghua University, published their research findings in Sc...

Recently, professors Rao Zihe and Yang Haitao at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University, together with their collaborators, have determined the high-resolution crystal structure of main protease (Mpro) from COVID-19 virus and identified drugs that may have promise against COVID-19. Invited by ...

Researchers from SIAIS of ShanghaiTech have been engaged in the race against COVID-19 since the epidemic broke out in January 2020. To accelerate the research work of specific drugs, a symposium on COVID-19 research work was held at SIAIS on March 24. The symposium was hosted by Dr. Jiang Ge, the Executive Director of SIAIS, Vice Provost of ShanghaiTech. Attendees included Dr. Yin Jie, Vice P...