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G protein-coupled receptors (GPCRs) located at the cell surface bind extracellular ligands and convey intracellular signals via activation of heterotrimeric G proteins. Traditionally, G protein signaling was viewed to occur exclusively at this subcellular region followed by rapid desensitization facilitated by β-arrestin-mediated G protein uncoupling and receptor internalization. However, emergin...

为纪念中国人民抗日战争暨世界反法西斯战争胜利80周年，形势与政策系列讲座邀请上海科技大学艺术总监，国家大剧院合唱团首任团长黄小曼老师带学生重温歌声里的抗战记忆，把不屈的奋斗精神传递给新时代青年。

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Cryo-EM is a powerful technique that can visualize biomolecules in their near-native state, but suffers from the low contrast of biospecimens and their sensitivity to electron radiation. A phase plate addresses this challenge by shifting the phase of the unscattered beam by exactly 90 degrees relative to the scattered electrons, thereby enhancing image contrast. In this talk I will present the de...

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Mitophagy is a selective form of autophagy for clearance of damaged mitochondria via the autophagy-lysosome pathway. Among various mitophagy regulatory mechanisms, PINK1, a protein kinase, and Parkin, an E3 ligase, are two critical players, with important implications in neurodegenerative disorders such as Parkinson's disease (PD). In this presentation, I will cover some of our recent work, includ...

Otolaryngology, commonly known as ENT, offers a unique convergence of sensory physiology, airway biomechanics, and human communication, making it an ideal domain for translational innovation. In this talk, Dr. Yike Li presents a multidisciplinary journey integrating neuroengineering, informatics, and clinical science. The first part introduces advances in neurostimulation for obstructive sleep apn...