Capturing totipotency in human and mouse cells by splicing repression
Zygotes and early blastomeres possess totipotency, which represents the highest level of developmental potency. While capturing totipotent stem cells in vitro with functionalities comparable to those of totipotent embryos in vivo remains challenging, our lab achieved a breakthrough in 2021 by stably culturing mouse totipotent blastomere-like cells (mTBLC) using splicing inhibition (Shen et al., 20...
2025-03-15