Food is one of the most important resources for the growth and development of all animals including humans. Along with other key factors, such as water and air, food is often the rate-limiting factor that determines the expansion and decay of the animal population, due to its relative scarcity in the environment. For this reason, animals have evolved a powerful nutrition-sensing system to cor...

On October 19, 2021, Assistant Professor He Shuijin’s group at SLST published a research article entitled “PUPIL enables mapping and stamping of transient electrical connectivity in developing nervous systems” in Cell Reports. In this study, they modified PUP-IT (developed by SLST Assistant Professor Zhuang Min, (read more at https://www.shanghaitech.edu.cn/eng/2018/0815/c1418a31492/p...

On October 20, Assistant Professor Liu Ru-Juan and her colleagues at SLST, together with her collaborators, published a research article entitled “THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates” in Nucleic Acids Research. This study reveals that THUMP domain-containing protein 3 (THUMPD3) interacts with an auxiliary protein (methyltransferase activato...

A team of scientists led by Prof. Chen Jia at the School of Life Science and Technology (SLST) of ShanghaiTech University, Prof. Yang Bei at Shanghai Institute of Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University, Prof. Yang Li at the Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences and Prof. Yin Hao at Wuhan University published a technical report article...

Sad tears from a lady can inhibit sexual impulse of a man. Why and how? Clues can be found from a recent study led by Professor Tong Xiajing at SLST. She and colleagues published a research article in the journal eLife entitled, “Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner. This study reveals how the ma...

Genomic imprinting is essential for mammalian embryonic development, and is an epigenetic phenomenon present in higher animals and plants. Dysregulation of the imprinted genes causes diabetes, cancer and neurological disorders. Understanding the expression regulation mechanism of imprinted genes can help us understand human individual development and disease etiology and treatment.  In a...

Recent studies have associated the aberrant accumulation of adipocytes in the heart  with many cardiovascular diseases such as arrhythmogenic right ventricular cardiomyopathy and heart failure. Therefore, understanding the cellular origins of cardiac adipocytes (CAs) has important implications for the treatment of fat-associated cardiovascular diseases. Recently, a team of scientist...

On December 1st, 2020, Professor Tiffany Horng from the SLST published an invited review article entitled “Lipid Metabolism in Regulation of Macrophage Functions” in the journal Trends in Cell Biology. In this review, Professor Horng and her postdoc Dr. Yan Jiawei describe the processes whereby signals that regulate macrophage activation influence lipid metabolic pathways and modulate macro...

On January 15, 2021, Professor Luo Zhenge and his colleagues at the School of Life Science and Technology (SLST) published a paper entitled, “TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a”, in the journal Science Advances. The cerebral cortex of mammals controls sensory input, motor output, learning and memory, deci...

A team of scientists led by Professor Zhang Hui from SLST has identified a novel potential therapeutic strategy to treat myocardial infarction. On November 20th, 2020, a paper entitled “Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction” was published online in Cell Research. &nbs...

A team of scientists led by Professor Lu Pengfei from SLST has discovered a novel multi-step mechanism by which vertebrate epithelium undergoes collective migration. On October 13, 2020 (Beijing time), their work was published online as a research article entitled, Asymmetric stratification-induced polarity loss and coordinated individual cell movements drive directional migration of vertebrate ep...

On September 2nd 2020, Professor Shen Wei from SLST with his collaborators published a research paper entitled “Parabrachial neuron types categorically encode thermoregulation variables during heat defense”, in the international academic journal Science in Advances. This paper defined two key elements of the lateral parabrachial nucleus (LPB)-hypothalamic preoptic area (POA) circu...

Recently, two groups from the School of Life Science and Technology (SLST) at ShanghaiTech University, led by Prof. Wang Huayi and Prof. Lu Junxia, published a research article entitled “RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif” in Cell Death & Differentiation.  Necroptosis is a type of programmed necrosis induced by ...

A research team led by Professor Zhang Hui from School of Life Science and Technology (SLST) at ShanghaiTech University has demonstrated that erythro-myeloid progenitors (EMPs) are the origin of resident macrophages in multiple organs, but not the origin of intraembryonic vascular endothelial cells. The team has written an article entitled “No Evidence for Erythro-Myeloid Progenitor-Derived Vascu...