• Epigenetic mechanism underlying human brain development identified
    On January 15, 2021, Professor Luo Zhenge and his colleagues at the School of Life Science and Technology (SLST) published a paper entitled, “TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a”, in the journal Science Advances. The cerebral cortex of mammals controls sensory input, motor output, learning and memory, deci...
    2021-01-15
  • SLST Researchers Propose a Potential Strategy to Treat Myocardial Infarction
    A team of scientists led by Professor Zhang Hui from SLST has identified a novel potential therapeutic strategy to treat myocardial infarction. On November 20th, 2020, a paper entitled “Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction” was published online in Cell Research. &nbs...
    2020-11-30
  • SLST Lab Discovers a New Mechanism of Vertebrate Epithelium Collective Migration
    A team of scientists led by Professor Lu Pengfei from SLST has discovered a novel multi-step mechanism by which vertebrate epithelium undergoes collective migration. On October 13, 2020 (Beijing time), their work was published online as a research article entitled, Asymmetric stratification-induced polarity loss and coordinated individual cell movements drive directional migration of vertebrate ep...
    2020-10-22
  • Shen Wei’s Lab Clarifies the Mechanism by Which Parabrachial Neurons Types Categorically Encode Thermoregulation Variables During Heat Defense
    On September 2nd 2020, Professor Shen Wei from SLST with his collaborators published a research paper entitled “Parabrachial neuron types categorically encode thermoregulation variables during heat defense”, in the international academic journal Science in Advances. This paper defined two key elements of the lateral parabrachial nucleus (LPB)-hypothalamic preoptic area (POA) circu...
    2020-09-04
  • SLST Proposes Novel Necroptosis Regulation Mechanisms
    Recently, two groups from the School of Life Science and Technology (SLST) at ShanghaiTech University, led by Prof. Wang Huayi and Prof. Lu Junxia, published a research article entitled “RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif” in Cell Death & Differentiation.  Necroptosis is a type of programmed necrosis induced by ...
    2020-08-24
  • SLST Researchers Solve the Controversy over Cellular Sources of Embryonic Vessels
    A research team led by Professor Zhang Hui from School of Life Science and Technology (SLST) at ShanghaiTech University has demonstrated that erythro-myeloid progenitors (EMPs) are the origin of resident macrophages in multiple organs, but not the origin of intraembryonic vascular endothelial cells. The team has written an article entitled “No Evidence for Erythro-Myeloid Progenitor-Derived Vascu...
    2020-08-24
  • SLST Researchers Reveal the Dynamics of SaCas9 in DNA Target Association and Dissociation
    A research team led by Professor Sun Bo from SLST has systemically investigated the molecular mechanism governing DNA binding, unwinding and cleavage by SaCas9. They provided a detailed dynamic understanding of SaCas9 in DNA target association and dissociation. In addition, two stable interactions between SaCas9 and DNA governing their interplay have been identified. On August 13, this study ...
    2020-08-13
  • ShanghaiTech Scientist Publishes a Review Article on Gene Editing Tools
    In a review article entitled “A Tale of Two Moieties: Rapidly-evolving CRISPR/Cas-based Genome Editing”, Prof. Chen Jia at School of Life Science and Technology (SLST) of ShanghaiTech University and Prof. Yang Li at CAS-MPG Partner Institute for Computational Biology (PICB) of Chinese Academy of Sciences, summarized recent progress about the development and application of gene editing tools...
    2020-07-03
  • SLST Researchers Report a Novel Mechanism of Linear Ubiquitination Regulating Autophagy Initiation and Maturation
    Recently, a research article entitled “LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13” was published online in Autophagy. This work was  done by Professor Liu Yanfen’s group from the School of Life Science and Technology (SLST) at ShanghaiTech University.  Autophagy is a self-eating sys...
    2020-06-30
  • Liu Ru-Juan’s Group Reveals Intellectual Disability-Associated Gene ftsj1 Modulates the Translation of Codon-Biased Genes
    On June 18, a research article entitled “Intellectual disability associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs” was published online in EMBO Reports. This work was done by Liu Ru-Juan’s group in the School of Life Science and Technology (SLST) at ShanghaiTech University and Wang En-Duo’s group from Shanghai Institute of Biochemistry and Cel...
    2020-06-19
  • ShanghaiTech Researchers Develop a Novel Therapeutic Strategy to Tackle IPEX-Like Disorders
    A team led by Professor Chi Tian from School of Life Science and Technology (SLST) at ShanghaiTech University proposed a new therapeutic strategy for IPEX-like disorders in a mouse model. They convert defective regulatory T cells (Treg) into super-activated Tregs (SuperTreg). The paper, entitled In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in...
    2020-06-08
  • BEACON: Efficient and Specific Base Editor with Low DNA Damage
    On June 3, 2020, a research article entitled “Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response” was published online in Cell Reports.  This work was done by a team led by Dr. Chen Jia from School of Life Science and Technology (SLST) at ShanghaiTech University, Dr. Yang Li from CAS-MPG Partner Institute for Computational Biology and Dr. L...
    2020-06-04
  • Scientists from ShanghaiTech and Tsinghua Universities Discover a Novel Neuroimmune Pathway
    On 29 April 2020, a research work carried out collaboratively by Professors Qi Hai and Zhong Yi from Tsinghua University and Professor Hu Ji from the School of Life Science and Technology (SLST) of ShanghaiTech University was published in Nature entitled “Brain control of humoral immune responses amenable to behavioural modulation”. The researchers identify a specific brain-spleen neur...
    2020-04-30
  • SLST Researchers Report a Novel Unwinding Model of a DNA Repair-Involved Helicase
    Recently, different research teams led by Professor Sun Bo from SLST and Professor Xi Xu-Guang from French National Centre for Scientific Research (CNRS) have collaboratively published a research article entitled “Human RPA activates BLM's bidirectional DNA unwinding from a nick” in the journal eLife, revealing a novel unwinding model of a DNA-repair-i...
    2020-03-09