• Development and application of transformer base editor
    A team of scientists led by Prof. Chen Jia at the School of Life Science and Technology (SLST) of ShanghaiTech University, Prof. Yang Bei at Shanghai Institute of Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University, Prof. Yang Li at the Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences and Prof. Yin Hao at Wuhan University published a technical report article...
    2021-05-11
  • SLST researchers discover sex-specific pheromone modulation of synaptic transmission
    Sad tears from a lady can inhibit sexual impulse of a man. Why and how? Clues can be found from a recent study led by Professor Tong Xiajing at SLST. She and colleagues published a research article in the journal eLife entitled, “Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner. This study reveals how the ma...
    2021-04-09
  • SLST researchers reveal a mechanism for allelic expression switch of imprinted genes
    Genomic imprinting is essential for mammalian embryonic development, and is an epigenetic phenomenon present in higher animals and plants. Dysregulation of the imprinted genes causes diabetes, cancer and neurological disorders. Understanding the expression regulation mechanism of imprinted genes can help us understand human individual development and disease etiology and treatment.  In a...
    2021-02-03
  • ShanghaiTech researchers reveal the origins of cardiac adipocytes
    Recent studies have associated the aberrant accumulation of adipocytes in the heart  with many cardiovascular diseases such as arrhythmogenic right ventricular cardiomyopathy and heart failure. Therefore, understanding the cellular origins of cardiac adipocytes (CAs) has important implications for the treatment of fat-associated cardiovascular diseases. Recently, a team of scientist...
    2021-02-03
  • SLST Professor Tiffany Horng discusses how lipid metabolism regulates macrophage function
    On December 1st, 2020, Professor Tiffany Horng from the SLST published an invited review article entitled “Lipid Metabolism in Regulation of Macrophage Functions” in the journal Trends in Cell Biology. In this review, Professor Horng and her postdoc Dr. Yan Jiawei describe the processes whereby signals that regulate macrophage activation influence lipid metabolic pathways and modulate macro...
    2021-01-30
  • Epigenetic mechanism underlying human brain development identified
    On January 15, 2021, Professor Luo Zhenge and his colleagues at the School of Life Science and Technology (SLST) published a paper entitled, “TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a”, in the journal Science Advances. The cerebral cortex of mammals controls sensory input, motor output, learning and memory, deci...
    2021-01-15
  • SLST Researchers Propose a Potential Strategy to Treat Myocardial Infarction
    A team of scientists led by Professor Zhang Hui from SLST has identified a novel potential therapeutic strategy to treat myocardial infarction. On November 20th, 2020, a paper entitled “Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction” was published online in Cell Research. &nbs...
    2020-11-30
  • SLST Lab Discovers a New Mechanism of Vertebrate Epithelium Collective Migration
    A team of scientists led by Professor Lu Pengfei from SLST has discovered a novel multi-step mechanism by which vertebrate epithelium undergoes collective migration. On October 13, 2020 (Beijing time), their work was published online as a research article entitled, Asymmetric stratification-induced polarity loss and coordinated individual cell movements drive directional migration of vertebrate ep...
    2020-10-22
  • Shen Wei’s Lab Clarifies the Mechanism by Which Parabrachial Neurons Types Categorically Encode Thermoregulation Variables During Heat Defense
    On September 2nd 2020, Professor Shen Wei from SLST with his collaborators published a research paper entitled “Parabrachial neuron types categorically encode thermoregulation variables during heat defense”, in the international academic journal Science in Advances. This paper defined two key elements of the lateral parabrachial nucleus (LPB)-hypothalamic preoptic area (POA) circu...
    2020-09-04
  • SLST Proposes Novel Necroptosis Regulation Mechanisms
    Recently, two groups from the School of Life Science and Technology (SLST) at ShanghaiTech University, led by Prof. Wang Huayi and Prof. Lu Junxia, published a research article entitled “RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif” in Cell Death & Differentiation.  Necroptosis is a type of programmed necrosis induced by ...
    2020-08-24
  • SLST Researchers Solve the Controversy over Cellular Sources of Embryonic Vessels
    A research team led by Professor Zhang Hui from School of Life Science and Technology (SLST) at ShanghaiTech University has demonstrated that erythro-myeloid progenitors (EMPs) are the origin of resident macrophages in multiple organs, but not the origin of intraembryonic vascular endothelial cells. The team has written an article entitled “No Evidence for Erythro-Myeloid Progenitor-Derived Vascu...
    2020-08-24
  • SLST Researchers Reveal the Dynamics of SaCas9 in DNA Target Association and Dissociation
    A research team led by Professor Sun Bo from SLST has systemically investigated the molecular mechanism governing DNA binding, unwinding and cleavage by SaCas9. They provided a detailed dynamic understanding of SaCas9 in DNA target association and dissociation. In addition, two stable interactions between SaCas9 and DNA governing their interplay have been identified. On August 13, this study ...
    2020-08-13
  • ShanghaiTech Scientist Publishes a Review Article on Gene Editing Tools
    In a review article entitled “A Tale of Two Moieties: Rapidly-evolving CRISPR/Cas-based Genome Editing”, Prof. Chen Jia at School of Life Science and Technology (SLST) of ShanghaiTech University and Prof. Yang Li at CAS-MPG Partner Institute for Computational Biology (PICB) of Chinese Academy of Sciences, summarized recent progress about the development and application of gene editing tools...
    2020-07-03
  • SLST Researchers Report a Novel Mechanism of Linear Ubiquitination Regulating Autophagy Initiation and Maturation
    Recently, a research article entitled “LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13” was published online in Autophagy. This work was  done by Professor Liu Yanfen’s group from the School of Life Science and Technology (SLST) at ShanghaiTech University.  Autophagy is a self-eating sys...
    2020-06-30