[SLST Seminar] cGAS-STING signaling in diseases

ON2024-03-26TAG: ShanghaiTech UniversityCATEGORY: Lecture

Topic: cGAS-STING signaling in diseases

Speaker: Professor Xu Pinglong, Life Science Institute, Zhejiang University (ZJU)

Date and time: 13:30–15:00, March 28

Venue: Auditorium of L Building

Host: Xi Ying


Dr.  Xu’s lab employs multidisciplinary approaches to systematically  elucidate the signaling mechanisms, biological functions, disease  implications, and intervention strategies of nucleic acid sensing, an  innate immune system. Dr. Xu identified the cGAS-STING-PERK signaling  pathway, proposed that nucleic acid sensing activation is a universal  mechanism leading to lysosomal storage disorders, discovered biological  functions of nucleic acid sensing related to protein synthesis, neuronal  loss, liquid-liquid phase separation, mitochondrial dynamics, and  cellular transdifferentiation, and revealed key mechanisms by which  nucleic acid sensing induces cellular senescence and fibrosis in the  lungs, kidneys, and liver, and advanced theories on how oncogenes, blood  glucose levels, nutritional microenvironments, and phase separation  control innate immune responses. His achievements have been published as  the corresponding author in prestigious journals such as Nature Cell Biology (2024, 2022, 2019, 2017), Molecular Cell (2022, 2021, 2020, 2014), Cell Host & MicrobeGenes & Development, PLoS Biology, Science Advances, and Journal of Hepatology.


  • Professor, Zhejiang University (2013–present)

  • Assistant Research Professor, University of California, San Francisco (2011–2013)

  • Postdoctoral Fellow, University of California, San Francisco (2004–2010)

  • PhD, Shanghai Institute of Biochemistry and Cell Biology (2003)