Recently, Prof. Shui Wenqing’s group from iHuman Institute and SLST has made a breakthrough in bioactive screening from herbal extracts. Based on their previous work in developing the affinity mass spectrometry (MS) technique for ligand screening (Chemical Science 2018, Analytical Chemistry 2019), they combined affinity MS-based screening with compound isolation and ...

Recently, Professor Liu Yu’s group from Center for Intelligent Power and Energy Systems (CiPES) of SIST, proposed two accurate fault location methods on long and complex transmission lines. These two papers were published online in IEEE Transactions on Power Delivery, the best peer-reviewed journal in the field of power system protection, transmission and distribution. High-voltage long...

Recently, scientists from Xu Fei's lab at iHuman Institute, ShanghaiTech University with their collaborators made a new breakthrough in the field of human cell signaling research. They successfully resolved the 3D protein structures of the first human orphan GPR52 receptor and presented a full structural landscape covering the receptor’s different functional states: ligand-free state, ligand-...

Magnetic topological insulators (MTIs), which integrate both topology and magnetism within one system, have greatly broadened the research scope of quantum materials and spintronics. In contrast to the traditional magnetic atom doping method, MTI heterostructures, which can be realized by the combination of a topological insulator and a high-temperature magnetic material, have unique advantages. I...

A team of scientists led by Professor Lu Pengfei from SLST has unexpectedly identified that the traditional tight junction protein Occludin does not act as a barrier in epithelial tissue as expected. Instead, Occludin plays a vital role in the regulation of extremely basic and important protein production and secretion. On February 13th, 2020, the work from Lu's lab was publishe...

On January 26th, professors Rao Zihe and Yang Haitao’s research team at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University determined the high-resolution crystal structure of SARS-CoV-2 3CL hydrolase (Mpro), the only public-domain 3D structure from SARS-CoV-2 currently. The structure data can be downloaded at PDB (Protein Data B...

When the epidemic of COVID-19 broke out, a joint research team was set up quickly, to enable research work on understanding the virusand accelerate the drug discovery. Led by professors Jiang Hualiang and Rao Zihe, the team is formed by over 20 research groups from SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech and Shanghai Institute of...

A team of scientists led by Professors Liu Zhi-Jie and Hua Tian at the iHuman Institute of ShanghaiTech University has determined and analyzed the high-resolution atomic structures of human cannabinoid receptors, also known as the “marijuana receptors”, 1 and 2 (CB1 and CB2) complexed with their agonists and downstream signaling G proteins. The results, described in a paper entitl...

Recently, the paper acceptance results of the 19th International Joint Conference on Autonomous Agents and Multi-Agent Systems (AAMAS-2020) and the 24th European Conference on Artificial Intelligence (ECAI-2020) have been announced. Five papers from Professor Zhao Dengji's research group of SIST were accepted. It is worth mentioning that the first authors of the accepted papers are n...

From January 8th to 9th, an International Assessment Committee conducted a comprehensive review of the School of Entrepreneurship and Management (SEM)’s first five years since its launch. The committee consisted of five internationally distinguished experts, chaired by Professor Richard Lyons (Chief Innovation & Entrepreneurship Officer and Former Dean of the Haas School of Business, UC Berke...

Research teams led by SPST Assistant Professor Ji Quanjiang and Fudan University Professor Gan Jianhua recently used structural biology, biochemical, and cell-based genome editing experiments to reveal the mechanisms of the PAM expansion and fidelity enhancement of a new evolved Cas9 nuclease xCas9. Their work, “Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuc...

iHuman Institute and SLST Professor Shui Wenqing’s group published a review in Current Opinion in Biotechnology in October 2019, “Systematic mapping of protein-metabolite interactions with mass spectrometry-based techniques”. This review presents a comprehensive overview of chemical proteomics techniques developed for probing protein-metabolite interactions in the cell. Shui Wenqing’...

A research group led by iHuman Institute and SLST Assistant Professor Zhao Suwen, working with Professor Wang Ming-Wei from Shanghai Institute of Materia Medica/The National Center for Drug Screening/Fudan University and Professor Babu Madan from MRC Laboratory of Molecular Biology, recently discovered a common activation pathway in class A GPCRs. Their study, “Common activation mechanism of clas...

Liquid sorbents, such as water, polyethylene glycol (PEG), and organic amine solutions, are widely used in many industrial processes for acid gases removal. This process is called wet scrubbing. However, most liquid sorbents have high vapor pressure and are sometimes even corrosive to the equipment. These undesirable features greatly increase the cost of separation and complicate facility design. ...