• Agonist-bound Marijuana Receptor Molecular Structure Determined
    Nature
    A team of scientists led by Professor Liu Zhijie at ShanghaiTech’s iHuman Institute has determined the 3-dimensional molecular structure of the agonist-bound human cannabinoid receptor CB1. The work reveals the structural features of agonist-bound CB1 and the activation mechanism of the receptor. The results, described in a paper entitled "Crystal structures of agonist-bound human canna...
    2017-07-14
  • Key Diabetes Receptor Structure Determined
    Nature
    An international team led by the iHuman Institute, ShanghaiTech University has determined the 3-dimensional molecular structure of the human glucagon-like peptide-1 receptor (GLP-1R) drug binding domain. The work reveals molecular mechanisms of allosteric regulation in class B G protein-coupled receptors (GPCRs). The results, described in a paper entitled “Human GLP-1 receptor transmemb...
    2017-05-18
  • Multi-domain Structure of Human Smoothened Receptor Deciphered
    Nature Communications
    A team of scientists led by the iHuman Institute of ShanghaiTech University in collaboration with Fudan University has determined the high-resolution crystal structure of the multi-domain human smoothened receptor. The results illustrate the allosteric domain-domain interactions within the receptor, and their role in smoothened activation. These new findings are published on May 17th, 2017 in...
    2017-05-18