At the Shanghai Science and Technology Award Conference held on March 23, 2018, Professor Kurt Hermann Wüthrich, distinguished professor of ShanghaiTech University’s iHuman Institute, was presented the 2017 Shanghai International Science and Technology Cooperation Award. Professor Wüthrich was appointed as Distinguished Professor of the iHuman Institute of ShanghaiTech University in 2013 a...

Polypharmacology is the next generation of disease treatment, promising more effective drugs that are less toxic and have fewer side effects. However, polypharmacological drugs, which simultaneously act on multiple targets, remain extremely difficult to develop, though maybe not for long, according to a study published this week in Cell.Apparently, the key lies in obtaining a better understanding ...

The 5th annual iHuman Forum, hosted by the iHuman Institute was successfully held at ShanghaiTech’s brand-new conference center on November 7-8th. The theme of the forum was "Imaging across the scales & Modeling supercomputer." The goal was to bring together scholars in the area of imaging across the molecular, cellular, and human scale, as well as gather great minds in th...

ShanghaiTech iHuman Institute Founding Director Dr. Raymond C. Stevens was awarded the 2017 Magnolia Silver Award in recognition of his great contribution to scientific research achievement and nurturing and mentoring of Chinese young scientists. Established by the Shanghai Municipal Government in 1989 and named after Shanghai's official flower, the Magnolia Award recognizes foreign experts an...

A team of scientists led by Professor Liu Zhijie at ShanghaiTech’s iHuman Institute has determined the 3-dimensional molecular structure of the agonist-bound human cannabinoid receptor CB1. The work reveals the structural features of agonist-bound CB1 and the activation mechanism of the receptor. The results, described in a paper entitled "Crystal structures of agonist-bound human canna...

An international team led by the iHuman Institute, ShanghaiTech University has determined the 3-dimensional molecular structure of the human glucagon-like peptide-1 receptor (GLP-1R) drug binding domain. The work reveals molecular mechanisms of allosteric regulation in class B G protein-coupled receptors (GPCRs). The results, described in a paper entitled “Human GLP-1 receptor transmemb...

A team of scientists led by the iHuman Institute of ShanghaiTech University in collaboration with Fudan University has determined the high-resolution crystal structure of the multi-domain human smoothened receptor. The results illustrate the allosteric domain-domain interactions within the receptor, and their role in smoothened activation. These new findings are published on May 17th, 2017 in...