Topic: Use of Physiologically Based Pharmacokinetic Modeling of Transporters: Predicting DDI, Non-Linearity and Target Tissue Exposure From in vitro to in vivo
Speaker: Yuichi Sugiyama, iHuman Distinguished Adjunct Professor, Josai International University, Tokyo, Japan
Date: October 11, Tuesday, 9:30 a.m.
Venue: Auditorium, Y Building
Host: SHUI Wenqing
Bio:
Yuichi Sugiyama started working as the Special Professor Emeritus in Josai Interanational University as of April 1, 2021. Before that, Dr. Sugiyama has been the Head of Sugiyama Laboratory, RIKEN, Yokohama, Japan since April 2012. He has been Professor, Dept of Molecular Pharmacokinetics at the University of Tokyo since 1991 until 2012. Dr. Sugiyama is acknowledged as a world-leader in the fields of physiologically based pharmacokinetics and membrane transporters. His work on physiologically based pharmacokinetics has been pivotal for quantitative in vitro-in vivo extrapolation, especially the development of models for the prediction of drug clearance and the magnitude of drug-drug interactions in humans. Further, his studies on membrane transporters, which encompass functional and kinetic characterization, and the impact of genetic variation, have been fundamental to our understanding of the role of transporters in drug disposition. Dr. Sugiyama has been the recipient of many awards, including the AAPS Award in 2003, FIP Host-Madsen Medal in 2009, Medal with Purple Ribbon given by Government of Japan in 2010, BB Brodie Award from ASPET in 2012, Rawls-Palmer Progress in Medicine Award from ASCPT in 2014, the RT Williams Distinguished Scientific Achievement Award from ISSX in 2013 and The Order of the Sacred Treasure, Gold Rays with Neck Ribbon by Government of Japan 2020. In addition to his scientific work, Dr Sugiyama has held leadership positions in several scientific organizations. In particular, he has served as the Presidents of ISSX and JSSX and strongly promoted worldwide drug metabolism, disposition, transporter research.
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