报告人简介：
Makoto Fujita is a University Distinguished Professor at The University of Tokyo in Japan. His main research interests have focused on coordination self-assembly, where nano-scale discrete frameworks are spontaneously formed through the action of weak interactions with transition-metal ions. He was awarded the 2018 Wolf Prize in Chemistry (shared with Prof. Omar Yaghi at UC Berkeley) for his contribution on metal-guided synthesis and "for conceiving metal-directed assembly principles leading to large highly porous complexes.".
讲座摘要：
For a long time, single crystal diffraction stands out as the most reliable, providing precise three-dimensional structures of molecules. In 2013, our group introduced a new X-ray structure analysis method termed the crystalline sponge (CS) method, eliminating the need for analyte crystallization. In this method, a small crystal of a porous complex (CS) is immersed in a solution containing the target compound, which is then absorbed and aligned within the CS pores. The post-oriented (or “post-crystallized”) target compound can then be observed alongside the host CS framework through crystallographic analysis. Despite its innovation, the CS method has certain limitations related to molecular size and polarity of analytes, etc. Here, an M6L4 cage, developed over the past three decades with extensive host-guest chemistry, is employed as a potent CS to address the several limitations of the original method. Large aromatic polysulfonates (“sticker” anions) significantly facilitated the crystallization to give cage-stacked single crystalline sponge (sc-1) . The symmetry mismatch between the cage (Td) and the sticker (D2h) resulted in a low space group (typically P1), avoiding the static guest disorder problem and leaving guest-accessible channels in the crystal. Guest accommodation in the cage cavity can be performed either before or after cage crystallization. Thanks to the cage’s large cavity with high guest-binding properties, a broader range of analytes can be analyzed, including water-soluble molecules, large amphiphilic molecules (MW ~1200), and molecular aggregates prior to reactions.
邀请人：甄家劲
Makoto Fujita is a University Distinguished Professor at The University of Tokyo in Japan. His main research interests have focused on coordination self-assembly, where nano-scale discrete frameworks are spontaneously formed through the action of weak interactions with transition-metal ions. He was awarded the 2018 Wolf Prize in Chemistry (shared with Prof. Omar Yaghi at UC Berkeley) for his contribution on metal-guided synthesis and "for conceiving metal-directed assembly principles leading to large highly porous complexes.".
讲座摘要：
For a long time, single crystal diffraction stands out as the most reliable, providing precise three-dimensional structures of molecules. In 2013, our group introduced a new X-ray structure analysis method termed the crystalline sponge (CS) method, eliminating the need for analyte crystallization. In this method, a small crystal of a porous complex (CS) is immersed in a solution containing the target compound, which is then absorbed and aligned within the CS pores. The post-oriented (or “post-crystallized”) target compound can then be observed alongside the host CS framework through crystallographic analysis. Despite its innovation, the CS method has certain limitations related to molecular size and polarity of analytes, etc. Here, an M6L4 cage, developed over the past three decades with extensive host-guest chemistry, is employed as a potent CS to address the several limitations of the original method. Large aromatic polysulfonates (“sticker” anions) significantly facilitated the crystallization to give cage-stacked single crystalline sponge (sc-1) . The symmetry mismatch between the cage (Td) and the sticker (D2h) resulted in a low space group (typically P1), avoiding the static guest disorder problem and leaving guest-accessible channels in the crystal. Guest accommodation in the cage cavity can be performed either before or after cage crystallization. Thanks to the cage’s large cavity with high guest-binding properties, a broader range of analytes can be analyzed, including water-soluble molecules, large amphiphilic molecules (MW ~1200), and molecular aggregates prior to reactions.
邀请人：甄家劲
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