首页 > iHuman研究所 > 师资队伍 > 刘志杰个人简介
刘志杰    副所长、正教授(生命学院)
所在学院 iHuman研究所
研究方向 结构生物学
联系方式 liuzhj@@shanghaitech.edu.cn
备注 百人
 
  个人简介  
1984年获得天津师范大学物理系学士学位;1994年获得中国科学院生物物理研究所生物物理学博士学位;1995-1995年在美国匹兹堡大学做博士后;1995-1997年在美国佐治亚大学做博士后;1997-2002年任美国佐治亚大学助理研究员;2002-2006年任美国佐治亚大学副研究员;2006-2013年任中国科学院生物物理研究所 “百人计划”研究员;2013年5月加入上海科技大学iHuman研究所。
  主要研究内容  
主要从事与人源细胞信号传导相关蛋白,如G蛋白偶联受体(GPCR),的结构生物学和基于结构的药物设计研究。研究工作集中在以下几个方面: 1、人源细胞信号传导相关蛋白的结构生物学研究; 2、基于GPCR三维结构的药物筛选与优化。
  代表性论文  
1) T. Hua, K. Vemuri, S.Nikas, R. Laprairie, Y. Wu, L. Qu, M. Pu, A. Korde, S. Jiang, J. Ho, Han G. W, K. Ding, Li X., H. Liu, M. Hanson, Zhao S*, L. Bohn*, A. Makriyannis*, R. Stevens, Liu ZJ* (2017) Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature, doi:10.1038/nature23272. 

2) Song G, Yang D, Wang Y, Graaf C.D, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han G.W, Lau J, Wu B, Hanson M.A, Liu Z.J*, Wang M.W*, and Steven R.C* (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, doi:10.1038/nature22378. 

3) T. Hua, K. Vemuri, M. Pu, L. Qu, GW. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N. Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn*, A. Makriyannis*, R Stevens*. Liu ZJ* (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167(3):750-762. 

4) Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. 6: 7300. 

5) Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu, ZJ*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58 

6) Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9. 

7) Jiao, L., OuYang, S., N., Liang, M., Niu, F., Shaw, N., Wu, W., Ding, W., Jin, C., Peng, Y., Zhu, Y., Zhang, F., Wang, T., Li, C., Zuo, X., Luan, C.*, Li., D.*, and Liu, Z. J*. (2013) Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid protein in Complex with Suramin Reveals Therapeutic Potentials. J. V, doi: 10.1128/JVI.00672-13.

8) Ru, H., Ni, X. , Zhao, L. , Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu, Z. J*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Res, 23(6):855-8. 

9) OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parv tiyar, K. Li, Y , Zhang, R., Cheng, G*. and Liu, Z. J*, (2012)  Structural Analysis of the STINGA daptor Proein Reveals a Hydropobic Dimer Interface an Mode of Cyclic d-GMP Binding, Immuity, 36(6): 1073-1086.

10) Liu, Z. J*, Chen, L., Wu, D., Ding, W., Zhang H., Zhou, W., Fu, Z. & Wang, BC*. (2011) A multi-dataset data-collection strategy produces better diffraction data. Acta Cryst A67, 544-549.

11) Shaw, N., OuYang, S, and Liu, Z. J*, (2012) Binding of bacterial secondary messenger molecule c di-GMP is a STING operation, Protein & Cell, Epub date 2012/12/25, doi 0.1007/s13238-012-2071-0.
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