The 3C protease has long been the focus of enterovirus antiviral development. Nevertheless, although anti-enterovirus drugs have a potentially enormous global market, the nucleophilic active site of 3C has frustrated previous drug discovery efforts. Recently, a team of scientists led by Dr. Yang Bei and Dr. Ian A. Wilson from the Laboratory of Antibody Structure at the Shanghai Institute for ...

On May 8, 2020, the Founding Ceremony was held for the Anti-Tuberculosis (TB) Structure Center (A-TB Center) of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University. The ceremony was followed by the First Academic Symposium of the A-TB Center at SIAIS. President Jiang Mianheng and Professor Rao Zihe at SIAIS, Member of the Chinese Academy of Sciences (CAS), joi...

A research group led by Prof. Katsuhiko Mikoshiba from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University proposes a novel and simple method for creating a stable cytoplasmic antibody, termed STAND, which can be correctly folded and stably expressed in the cytoplasm of the cells. Without the need for complicated amino acid substitutions, it successfully conve...

At 2:00 AM (Beijing Time) on 24th April, a research article titled “Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol” as reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), was published via First Release in Science. This work, for...

Recently, Research Associate Professors Liu Jia, from Lab of Macromolecular Drug Delivery and Ma Peixiang,from Lab of Phenotypic Screening at SIAIS, ShanghaiTech University, reported the first anti-CRISPR peptides. These peptides are derived from the periplasmic domain of the major coat protein G8P (G8PPD) of inoviridae bacteriophages and can allosterically inactivate...

On April 10, 2020, a joint research team led by Rao Zihe, Distinguished Adjunct Professor at SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, Wang Quan, Assistant Professor at School of Life Science and Technology (SLST) and SIAIS, ShanghaiTech University and Lou Zhiyong, Research Professor at Tsinghua University, published their research findings in Sc...

Recently, professors Rao Zihe and Yang Haitao at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University, together with their collaborators, have determined the high-resolution crystal structure of main protease (Mpro) from COVID-19 virus and identified drugs that may have promise against COVID-19. Invited by ...

Researchers from SIAIS of ShanghaiTech have been engaged in the race against COVID-19 since the epidemic broke out in January 2020. To accelerate the research work of specific drugs, a symposium on COVID-19 research work was held at SIAIS on March 24. The symposium was hosted by Dr. Jiang Ge, the Executive Director of SIAIS, Vice Provost of ShanghaiTech. Attendees included Dr. Yin Jie, Vice P...

Recently, a joint research team led by Rao Zihe, Distinguished Adjunct Professor at SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, Wang Quan, Assistant Professor at School of Life Science and Technology (SLST) and SIAIS, ShanghaiTech University and Lou Zhiyong, Associate Professor at Tsinghua University, reported a 2.9 Å cryo-EM structure of the RNA-d...

On January 26th, professors Rao Zihe and Yang Haitao’s research team at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University determined the high-resolution crystal structure of SARS-CoV-2 3CL hydrolase (Mpro), the only public-domain 3D structure from SARS-CoV-2 currently. The structure data can be downloaded at PDB (Protein Data B...

When the epidemic of COVID-19 broke out, a joint research team was set up quickly, to enable research work on understanding the virusand accelerate the drug discovery. Led by professors Jiang Hualiang and Rao Zihe, the team is formed by over 20 research groups from SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech and Shanghai Institute of...

Dr. Yang Haitao, Shanghai Institute of Advanced Immunochemical Institute (SIAIS) Principal Investigator, recently was awarded the 2019 Youth Shu Lan Medicine Award, marking the first time a ShanghaiTech faculty member won this  prize.Youth Shu Lan Medicine Award Winners and the PresentersThe Shu Lan Medicine Awards, first awarded in 2014, recognize distinguished scientists and scholars. Youth...

In November, SIAIS Professor Katsuhiko Mikoshiba and Research Associate Professor Kozo Hamada of Cell Calcium Signaling laboratory published a review paper entitled ‘IP3 Receptor Plasticity Underlying Diverse Functions’ in Annual Review of Physiology. The paper reviews recent progress on the IP3 receptor structure and function, and the authors propose a new concept of how protein plast...

SIAIS Principal Investigator Dr. Rao Zihe and his team recently unveiled the 3-dimensional structure of the African swine fever (ASF) virus, a giant and complex virus which causes a contagious and lethal swine disease all over the world. The study, entitled ‘Architecture of African swine fever virus and implications for viral assembly,’ was published in Science on Oct 17th.  Since...