|1997-2001, B.S. Biochemistry, Department of Biochemistry, Nanjing University, Nanjing, China
2011-2006, Ph.D. Neuroscience, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China
2006-2010, Postdoctoral fellow, MIT, Cambridge, Massachusetts, USA
2011-2017, Associate Professor, School of Life Science, Tsinghua University, Beijing, China
2017-now, Associate professor, PI, School of Life Science and Technology, ShanghaiTech University, Shanghai, China
|The lab has been focusing on exploring the circuitry and molecular mechanisms underlying memory formation and retrieval. We developed an in vivo imaging tool and data analysis system to directly measure the memory-related cortical responses in large scale. Combined with optogenetic and chemogenetic tools, we identified the memory trace neurons in layer 2 cortex and hippocampal dentate gyrus area and studied their dynamic activity of memory traces, underlying the long-term memory. Furthermore, a mechanism of epigenetic regulation was discovered within memory trace neurons to modulate the memory stability.|
a) Xinlu Ding, SanXiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, HaiTeng Deng, Yichang Jia, Wei Xie, Hong Xie & Ji-Song Guan# (2017) Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation. Nat Neurosci. May;20(5):690-699 doi:10.1038/nn.4536
b) Zhu Τ, Liang C, Li D, Tian M, Liu S, Gao G and Guan JS#. (2016) Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α. Sci Rep. 6: 26597.
c) Guan JS#, Jiang J, Xie H and Liu K-Y. (2016) How does the sparse memory "Engram": Neurons encode the memory of a spatial-temporal event? Front. Neural Circuits 10: 61. (Review)
d) Guan JS#, Xie H, Ding XL. (2015) The role of epigenetic regulation in learning and memory. Exp Neuro. 268: 30-36.
e) Xie H, Liu Y, Zhu YZ, Ding XL, Yang YH and Guan JS#. (2014) In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A. 111: 2788-2793.
f) Guan JS*, Su SC*, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr SA and Tsai LH. (2011) Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLoS One 6: e25735.
g) Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I and Tsai LH. (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483: 222-226.
h) Guan JS*, Haggarty SJ*, Giacometti E*, Dannenberg JH*, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang XY, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R and Tsai LH. (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459: 55-60. (full research article)
i) Guan JS*, Xu ZZ*, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L and Zhang X (2005) Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell 122: 619-631.