Hui Zhang    Assistant Professor, PI
Institute School of Life Science and Technology
Research Area Cardiovascular development and diseases
Contact Info. zhanghui1@@shanghaitech.edu.cn
 
  Biography  
2004.09-2008.06, B.A. in College of Animal Sciences and Technology, Huazhong Agriculture University;
2008.09-2014.03, Ph.D. in Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;
2014.04-2016.03, Postdoc in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;
2016.04-2016.10, Research fellow in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;
2016.11 to Present, Assistant Professor, PI in School of Life Science and Technology, ShanghaiTech University.
        My previous work focused on cardiac development, especially endocardial development. Taking advantage of genetic lineage tracing, we identified the multipotency of embryonic endocardial endothelial cells, which could differentiate into cushion mesenchymal cells (Zhang et al, J Biol Chem, 2014), coronary endothelial cells (Tian et al, Cell Res, 2013; Tian et al, Science, 2014; Zhang et al, Circ Res, 2016), hepatic vascular endothelial cells (Zhang et al, Nat Genet, 2016), intramyocardial adipocytes (Zhang et al, Circ Res, 2016), and coronary mural cells (Chen et al, 2016, Nat Commun).
  Research Interests  
The cardiomyocytes of adult mammalian animals (such as human, mouse) have limited proliferation ability. Cardiomyocyte loss and fibrosis formation after cardiac injury (such as myocardial infarction) will result in heart failure and even death. However, the embryonic and neonatal cardiomyocytes have a strong ability to proliferate, which facilitates the regeneration of embryonic or neonatal hearts. Therefore, we are interested in the study of cardiovascular development and how to promote adult cardiac regeneration after injury.
At present, we have generated a variety of mouse genetic tools and developed different disease models (such as myocardial infarction and apex resection). Utilizing lineage tracing and tissue-specific gene manipulation, we are to discover cell fate conversions of different cell types (such as cardiomyocyte progenitor cells, coronary endothelial cells, mesenchymal cells) and their molecular mechanisms during cardiovascular development, pathogenesis and regeneration. Our goals are to develop new potential treatment targets and improve repair and regeneration abilities of cardiovascular system.
  Selected Publications  
Representative publications:
1. Tian X#, Hu T#, Zhang H#, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell research. 2013;23:1075-1090 (Cover story
2. Tian X#, Hu T#, Zhang H#, He L#, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014;345:90-94
3. Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014;289:18681-18692
4. Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B. Endocardium contributes to cardiac fat. Circulation research. 2016;118:254-265
5. Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nature genetics. 2016;48:537-543 
6. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B. Endocardium minimally contributes to coronary endothelium in the embryonic ventricular free walls. Circulation research. 2016;118:1880-1893 (Cover story
7. Zhang H#*, Huang X#, Liu K#, Tang J#, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang Q, Qiao Z, Zhang L, Lui K, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell research. 2017;27(9)

Other publications:
1. Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. Journal of molecular and cellular cardiology. 2012;52:43-47
2. Tian X, Hu T, He L, Zhang H, Huang X, Poelmann RE, Liu W, Yang Z, Yan Y, Pu WT, Zhou B. Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PloS one. 2013;8:e80857
3. He L, Tian X, Zhang H, Wythe JD, Zhou B. Fabp4-creer lineage tracing reveals two distinctive coronary vascular populations. Journal of cellular and molecular medicine. 2014;18:2152-2156
4. He L, Tian X, Zhang H, Hu T, Huang X, Zhang L, Wang Z, Zhou B. Baf200 is required for heart morphogenesis and coronary artery development. PloS one. 2014;9:e109493
5. Liu Q, Huang X, Zhang H, Tian X, He L, Yang R, Yan Y, Wang QD, Gillich A, Zhou B. C-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nature medicine. 2015;21:866-868
6. Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B. Genetic targeting of sprouting angiogenesis using apln-creer. Nature communications. 2015;6:6020
7. Liu Q, Zhang H, Tian X, He L, Huang X, Tan Z, Yan Y, Evans SM, Wythe JD, Zhou B. Smooth muscle origin of postnatal 2nd cvp is pre-determined in early embryo. Biochem Biophys Res Commun. 2016;471:430-436
8. Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang QD, Lui KO, Zhou B. Genetic lineage tracing identifies in situ kit-expressing cardiomyocytes. Cell research. 2016;26:119-130
9. He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD, Zhou B. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovascular research. 2016;109:419-430
10. Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui K, Zhou B. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nature communications. 2016;7:13369
11. Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nature communications. 2016;7:12422
12. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B. Gata4 regulates fgf16 to promote heart repair after injury. Development. 2016;143:936-949
13. Lu J, Zhou Y, Hu T, Zhang H, Shen M, Cheng P, Dai W, Wang F, Chen K, Zhang Y, Wang C, Li J, Zheng Y, Yang J, Zhu R, Wang J, Lu W, Zhang H, Wang J, Xia Y, De Assuncao TM, Jalan-Sakrikar N, Huebert RC, Bin Z, Guo C. Notch signaling coordinates progenitor cell-mediated biliary regeneration following partial hepatectomy. Scientific reports. 2016;6:22754
14. He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest. 2017;127(8):2968-2981

(# first author;*Corresponding author)
浏览次数:490