|Dr. Yan Zou graduated from Department of Biology of Nanchang University, and received a doctor degree from Institute of Genetics and Developmental Biology of Chinese Academy of Sciences in 2007. She was a Postdoctoral Fellow between 2008 and 2013 and a Research Associate between 2013 and 2014 in the Department of Developmental Biology at Cincinnati Children’s Hospital Research Foundation in the United States. Since 2014, she joins School of Life Sciences and Technology at ShanghaiTech University as an assistant professor (Tenure-track), PI.|
|We are interested in understanding the mechanisms underlying the complex pattern of neuronal wiring during development and regeneration after injury. Precise assembly of neuronal circuits is critical for proper functions of the nervous system, such as perception, memory and the control of movement. The complex patterns of neuronal wiring in the nervous system are regulated in the precise direction at the appropriate time. We want to study the mechanisms underlying the precise regulations of neuronal assembly using C.elegans as a model organism. In addition, we are also interested in investigating negative regulators of axon growth that limit the brain’s ability to grow out axon, especially when neurons age, since they provide therapeutic targets for developing strategies to treat brain and spinal cord injuries.|
1. Zou, Y.*, Chiu, H.*, Zinovyeva, A., Ambros, V., Chuang, C-F., Chang, C. (2013).Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science 340, 372-376. (Featured in "Perspective” in Science; Highlighted in"Editors' Choice” in Science Signaling; Recommended by Faculty of 1000; *Equal contribution)
2. Zou, Y., Chiu, H., Domenger, D., Chuang, C.F., Chang, C. (2012). The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction. Science Signaling 5, research article ra43.
3. Xiang, T.*, Zong, N.*, Zou, Y.*, Wu, Y., Zhang, J., Xing, W., Li, Y., Tang, X., Zhu, L., Chai, J., and Zhou, J. M. (2008). Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Current Biology 18, 74-80. (*Equal contribution)
4. Xing, W., Zou, Y. *, Liu, Q. *, Liu, J., Luo, X., Huang, Q., Chen, S., Zhu, L., Bi, R., Hao, Q., Wu, J. W., Zhou, J. M. and Chai, J. (2007). The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature 449, 243-247. (*Equal contribution)