Topic: Developing structural interactomics and its application in biology
Speaker: Dr. LIU Fan, Structural Interactomics, Leibniz-Forschungsinstitut for Molecular Pharmacology (Leibniz-FMP)
Date and time: 15:00, September 15
Venue: Auditorium of L Building
Host: Wolfgang Baumeister
Abstract:
Profiling human interactome is critical in understanding the molecular basis for nearly all processes of life. Over the years, we’ve advanced crosslinking mass spectrometry by developing experimental methods and software tools to identify tens of thousands of PPIs from whole cells. These data reveal numerous aspects of living systems—for example, protein subcellular localizations, virus-host interactions, and architectures of suprabiomolecular machineries. Furthermore, these data offer unprecedented opportunities to profile interactome changes between tissues and disease states, providing invaluable training data for Al-based methods to identify PPI-mediating motifs, inform new protein/antibody designs and screen for drug targets.
Biography:
2017–Present, Group Leader and head of the proteomics research platform at Leibniz-Forschungsinstitut for Molecular Pharmacology
2013–2017, Postdoctoral in the lab of Prof. Dr. Albert Heck at Utrecht
2007–2013, Ph.D. in Biochemistry in the lab of Prof. Dr. Mike Goshe at North Carolina State University